The bone marrow: a nest for migratory memory T cells
The bone marrow: a nest for migratory memory T cells
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DOI：
10.1016/j.it.2005.04.011
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发表时间：
2005-07-01
影响因子：
16.8
通讯作者：
Pabst, R
中科院分区：
文献类型：
--
作者：
Di Rosa, F;Pabst, R
长期以来，人们已经知道骨髓中产生的T细胞前体迁移到胸腺，在胸腺中发生T细胞发育。然而，一个经常被忽视的事实是，在生理条件下，成熟的CD4和CD8淋巴细胞经历从血液到骨髓的广泛迁移，反之亦然。在这里，我们首先回顾了几个观察结果表明，骨髓可以作为一个二级淋巴器官的CD4和CD8细胞，以及一个优先归巢网站的记忆T细胞。其次，我们讨论了这样的证据：在引发后很长一段时间，记忆CD 8细胞在骨髓中比在次级淋巴或淋巴外器官中增殖得更广泛。最后，我们提出骨髓是成熟T细胞运输的中心器官，对长期细胞毒性记忆有很大贡献，这对过继免疫治疗和疫苗设计有影响。
It has been known for a long time that T-cell precursors generated in the bone marrow migrate to the thymus, where T-cell development occurs. However, a fact often neglected is that, under physiological conditions, mature CD4 and CD8 lymphocytes undergo extensive migration from the blood to the bone marrow and vice versa. Here, we first review several observations showing that the bone marrow can function as a secondary lymphoid organ for both CD4 and CD8 cells, as well as a preferential homing site for memory T cells. Second, we discuss evidence that, a long time after priming, memory CD8 cells proliferate more extensively in the bone marrow than they do in either secondary lymphoid or extra-lymphoid organs. Finally, we propose that the bone marrow is a central organ in mature T-cell traffic and contributes greatly to long-term cytotoxic memory, which has implications for adoptive immunotherapy and vaccine design.