Methods for the Measurement of Platelet Function
Methods for the Measurement of Platelet Function
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DOI：
10.1016/j.amjcard.2008.11.019
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发表时间：
2009-02-02
影响因子：
2.8
通讯作者：
Michelson, Alan D.
中科院分区：
文献类型：
--
作者：
Michelson, Alan D.
本文讨论了血小板功能测定方法的优缺点。重点是可用于监测心血管疾病背景下抗血小板活性的测试，并可能预测血栓形成和出血。所描述的测试是血小板聚集测定法;阻抗聚集测定法; VerifyNow（Accumetrics，San Diego，CA）;血小板工作（Helena Laboratories，博蒙，TX）;血小板表面P-选择素、血小板表面活化糖蛋白IIb/IIIa和白细胞-血小板聚集体; TEG血小板图谱系统（Haemoscope，奈尔斯，IL）;冲击锥板（let）分析仪（DiaMed，Cressier，瑞士）;血小板功能分析仪-100（Siemens Healthcare Diagnostics，Inc.，Deerfield，IL）;血管舒张刺激磷蛋白磷酸化;血清血栓素132;和尿11-β血栓素B（2）。区分这些测试的一些因素是样本体积要求，全血的使用，剪切的存在，护理点状态，对技术人员的需求和费用。(C)2009年由Elsevier Inc.出版(Am J Cardiol 2009;103[suppl]：20A-26A）
This article discusses the advantages and disadvantages of methods for the measurement of platelet function. The focus is on tests that can be used to monitor antiplatelet activity in the setting of cardiovascular disease and potentially predict thrombosis and bleeding. The tests described are platelet aggregometry; impedance aggregometry; VerifyNow (Accumetrics, San Diego, CA); Plateletworks (Helena Laboratories, Beaumont, TX); platelet surface P-selectin, platelet surface-activated glycoprotein IIb/IIIa, and leukocyte-platelet aggregates; TEG Platelet Mapping system (Haemoscope, Niles, I L); Impact cone and plate(let) analyzer (DiaMed, Cressier, Switzerland); Platelet Function Analyzer-100 (Siemens Healthcare Diagnostics, Inc., Deerfield, IL); phosphorylation of vasodilator-stimulated phosphoprotein; serum thromboxane 132; and urinary 11-dehydro thromboxane B(2). Some of the factors that differentiate these tests are sample volume requirements, the use of whole blood, the presence of shear, point-of-care status, need for a technician, and expense. (C) 2009 Published by Elsevier Inc. (Am J Cardiol 2009;103[suppl]:20A-26A)