Induction of benzo[α]pyrene hydroxylase activity in rat skin
Induction of benzo[α]pyrene hydroxylase activity in rat skin
复制标题
诱导大鼠皮肤苯并[α]芘羟化酶活性
DOI：
10.1016/0024-3205(70)90129-3
复制
发表时间：
1970
期刊：
影响因子：
6.1
通讯作者：
A. Conney
中科院分区：
文献类型：
--
作者：
E. Schlede;A. Conney
尽管对照大鼠的皮肤中很少或没有苯并[α]芘羟化酶（BP-羟化酶）活性，但将3-甲基胆蒽应用于大鼠皮肤可迅速诱导该组织中的BP-羟化酶活性。单次使用 3-甲基胆蒽后 24 小时，皮肤中的 BP-羟化酶活性增加数倍。
Although little or no benzo[α]pyrene hydroxylase (BP-hydroxylase) activity was present in the skin of control rats, application of 3-methylcholanthrene to rat skin rapidly induced BP-hydroxylase activity in this tissue. BP-hydroxylase activity in skin was increased several-fold at 24 hours after a single application of 3-methylcholanthrene.