Season of birth and vulnerability to the pathology of Alzheimer's disease: an in vivo positron emission tomography study.
Season of birth and vulnerability to the pathology of Alzheimer's disease: an in vivo positron emission tomography study.
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出生季节和阿尔茨海默病病理学的脆弱性：一项体内正电子发射断层扫描研究。
DOI：
10.1111/psyg.12838
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发表时间：
2022
期刊：
影响因子：
2
通讯作者：
Minami H
中科院分区：
文献类型：
--
作者：
Yasuno F;Minami H
本研究使用正电子发射断层扫描来研究出生季节效应作为早期生活环境因素的外源性指标是否会影响老年人对阿尔茨海默病(AD)病理的易感性。方法我们分析了阿尔茨海默病神经成像计划的数据，其中包括234名认知正常(CN)个人和轻度认知障碍(MCI)患者(n=1114)和AD痴呆患者(n=1838)。作为淀粉样蛋白β(Aβ)/tau蓄积的指标，通过协方差分析比较了春夏和秋冬两组新生儿的18F-AV-45和18F-AV-1451标准化摄取值比值。此外，对出生季节是否为18F-AV-45和/或18F-AV-1451的影响因素进行多元线性回归分析。我们发现，在CN和MCI/AD组中，在校正了年龄、性别、教育年限和阿尔茨海默病评估量表认知分量表的影响后，在CN和MCI/AD组中，秋冬出生的参与者显示出比春夏出生的参与者更低的18F-AV-1451 SUVR，这可能会影响tau的积累。结论在考虑了可能影响tau积累的因素后，秋冬出生的参与者比春夏出生的参与者表现出更少的tau积累。我们的发现显示，秋冬出生的参与者容易受到tau病理的影响，这可能是由于与寒冷季节相关的风险因素造成的围产期或出生后脑损伤所致。
BackgroundThis study used positron emission tomography to examine whether the seasonal birth effect as an exogenic indicator of early life environmental factors influenced vulnerability to Alzheimer's disease (AD) pathology in the elderly.MethodsWe analysed datasets from the Alzheimer's Disease Neuroimaging Initiative, which included the data for 234 cognitively normal (CN) individuals and patients with mild cognitive impairment (MCI) (n= 114) and AD dementia (n= 38). As an index of amyloid β (Aβ)/tau accumulation, the18F‐AV‐45‐ and18F‐AV‐1451‐standardized uptake value ratios (SUVRs) were compared between groups of spring‐to‐summer births and fall‐to‐winter births by analysis of covariance. In addition, a multiple linear regression analysis was performed to determine whether the season of birth was a predictor of18F‐AV‐45 and/or18F‐AV‐1451 SUVRs, for which a difference was observed.ResultsSeasonal birth difference was a good predictor of18F‐AV‐1451 SUVR. We found that participants with a fall‐to‐winter birth showed lower18F‐AV‐1451 SUVRs than those with a spring‐to‐summer birth in both the CN and MCI/AD groups, after correcting for the effect of age, sex, years of education, and Alzheimer's Disease Assessment Scale cognitive subscale score, that could possibly affect tau accumulation.ConclusionsParticipants with a fall‐to‐winter birth showed less tau accumulation than those with a spring‐to‐summer birth after accounting for the factors that could affect tau accumulation. Our findings showed a vulnerability to tau pathology in participants with a fall‐to‐winter birth, which may be caused by perinatal or postnatal brain damage due to the risk factors associated with the cold season.