Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory
Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory
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DOI：
10.3389/fnins.2020.00022
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发表时间：
2020-01-29
影响因子：
4.3
通讯作者：
Hitoshi, Seiji
中科院分区：
文献类型：
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作者：
Daun, Kenny Anak;Fuchigami, Takahiro;Hitoshi, Seiji
早期生活压力可以对神经发育和出生后行为产生不利或有益的影响，具体取决于时间、持续时间、强度和控制应激源的能力。在这项研究中，我们利用母体和社会剥夺(MSD)模型来研究早期生活应激对成年大脑中神经干细胞(NSCs)和神经发生的影响。我们发现，在应激-低反应期(SHRP)期间的MSD(早期-MSD)，当皮质酮分泌被抑制时，增加了NSC群体的规模，而超过SHRP的相同的应激则取消了这些影响。早期MSD不仅增强了海马齿状回的神经发生，这是经典的神经源性区域之一，而且还促进了杏仁核的神经发生。此外，暴露于早期MSD的小鼠表现出杏仁核/海马体依赖的恐惧记忆的减少。这些结果表明，在SHRP期间暴露于早期生活应激的动物具有增强的应激韧性，以应对感知到的应激源，以维持正常的体内平衡状态。
Early life stress can exert detrimental or beneficial effects on neural development and postnatal behavior depending on the timing, duration, strength, and ability to control the stressors. In this study, we utilized a maternal and social deprivation (MSD) model to investigate the effects of early life stress on neural stem cells (NSCs) and neurogenesis in the adult brain. We found that MSD during the stress-hyporesponsive period (SHRP) (early-MSD), when corticosterone secretion is suppressed, increased the size of the NSC population, whereas the same stress beyond the SHRP abrogated these effects. Early-MSD enhanced neurogenesis not only in the dentate gyrus of the hippocampus, one of the classic neurogenic regions, but also in the amygdala. In addition, mice exposed to early-MSD exhibited a reduction in amygdala/hippocampus-dependent fear memory. These results suggest that animals exposed to early life stress during the SHRP have reinforced stress resilience to cope with perceived stressors to maintain a normal homeostatic state.