A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier
A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier
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DOI：
10.1006/viro.1996.0239
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发表时间：
1996-05-01
期刊：
影响因子：
3.7
通讯作者：
Ertl, HCJ
中科院分区：
文献类型：
--
作者：
Xiang, ZQ;Yang, YP;Ertl, HCJ
在这篇手稿中，测试了在巨细胞病毒早期启动子控制下表达狂犬病病毒糖蛋白（G 蛋白）的 E1 和 E3 缺失腺病毒重组体在小鼠中诱导狂犬病病毒特异性免疫反应。发现该构建体可诱导狂犬病病毒的中和抗体和溶细胞 T 细胞。通过全身途径或通过气道施用腺病毒构建体进行疫苗接种的小鼠可以免受随后狂犬病病毒毒株的感染。复制缺陷构建体的功效远远优于已充分表征的狂犬病痘苗糖蛋白重组体。 (C) 1996 学术出版社
In this manuscript, an E1 and E3 deleted adenoviral recombinant expressing the rabies virus glycoprotein (G protein) under the control of the cytomegalovirus early promoter was tested for induction of a rabies virus-specific immune response in mice. The construct was found to induce neutralizing antibodies and cytolytic T cells to rabies virus. Mice vaccinated with the adenoviral construct either by the systemic route or by application into the airways were protected against a subsequent infection with a virulent strain of rabies virus. The efficacy of the replication-defective construct was far superior to that of a well-characterized vaccinia rabies glycoprotein recombinant. (C) 1996 Academic Press, Inc.