The therapeutic potential of neuropeptide Y. Analgesic, anxiolytic and antihypertensive.
The therapeutic potential of neuropeptide Y. Analgesic, anxiolytic and antihypertensive.
复制标题
DOI：
--
复制
发表时间：
1996
期刊：
影响因子：
11.5
通讯作者：
R. Munglani;M. Hudspith;S. Hunt
中科院分区：
文献类型：
--
作者：
R. Munglani;M. Hudspith;S. Hunt
神经肽Y(NPY)自1982年被发现以来，在中枢神经系统和外周神经系统中都被证明由越来越多的NPY受体介导而发挥多种作用。也许最值得注意的是NPY在控制全身血压方面的作用，以及它对进食、焦虑和记忆的影响。然而，最近的证据越来越多地支持NPY通过不同的中枢和外周机制在介导镇痛和痛觉过敏中发挥重要作用。在这篇综述中，我们集中在NPY药理学的这一重要方面，并考虑控制NPY及其受体表达的机制。此外，我们还提供了更新的数据，描述了NPY-NPY激动剂和拮抗剂在治疗厌食、癫痫、焦虑、抑郁、高血压和心力衰竭等疾病中可能发挥的其他作用。
Since its discovery in 1982, neuropeptide Y (NPY) has been shown to have numerous effects mediated by a growing number of NPY receptors in both the CNS and peripheral nervous system. Perhaps best appreciated is the role of NPY in the control of systemic blood pressure, together with its effects on feeding, anxiety and memory. However, recent evidence increasingly supports an important role for NPY in mediating analgesia and hyperalgesia by distinct central and peripheral mechanisms. In this review we concentrate on this important aspect of NPY pharmacology and consider mechanisms controlling the expression of NPY and its receptors. In addition, we also present the more recent data describing the other possible roles for NPY-NPY agonists and antagonists may be useful in the treatment of conditions as varied as anorexia, epilepsy, anxiety, depression, hypertension and heart failure.