A potential inhibitory function of draxin in regulating mouse trunk neural crest migration.
A potential inhibitory function of draxin in regulating mouse trunk neural crest migration.
复制标题
Draxin在调节小鼠躯干神经rest迁移中的潜在抑制功能。
DOI：
10.1007/s11626-016-0079-0
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Tanaka H
中科院分区：
文献类型：
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作者：
Zhang S;Su Y;Gao J;Zhang C;Tanaka H
Draxin是一种排斥性轴突引导蛋白，在鸡脊髓中枢神经系统和背间神经元3 （dI3）的形成中起重要作用。在本研究中，我们报道了小鼠draxin在小鼠胚胎干脊髓中的表达模式。在draxin存在的情况下，迁移小鼠干神经嵴细胞的最长净迁移长度明显缩短。此外，极性神经嵴细胞的相对数量随德拉辛处理时间的延长而增加。德拉辛引起迁移主干神经嵴细胞的肌动蛋白骨架重排。我们的数据表明，德拉辛可能通过细胞肌动蛋白骨架的重排和随后降低这些细胞的极化活性来调节小鼠干神经嵴细胞的迁移。
Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently.