OXYTOCIN INDUCES MATERNAL-BEHAVIOR IN VIRGIN FEMALE RATS
OXYTOCIN INDUCES MATERNAL-BEHAVIOR IN VIRGIN FEMALE RATS
复制标题
DOI：
10.1126/science.7071605
复制
发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
PRANGE, AJ
中科院分区：
文献类型：
--
作者：
PEDERSEN, CA;ASCHER, JA;PRANGE, AJ
雌性处女大鼠去卵巢后48小时脑室注射催产素，可迅速产生完全的母性行为。母性行为持续存在，其发生率与剂量相关。催产素的环结构托卡酸也迅速诱导了持续的、完整的母性行为的发生。精氨酸加压素诱导了持续的母性行为，但这种行为起病较晚。前列腺素[PG]F2α。诱发了强烈的部分母性行为，表现为起病早但不持久。许多其他多肽、卵巢类固醇和PGE2并不比生理盐水更有效。催产素和前列腺素F2α的释放。在分娩期间，可能会促进大鼠的母性行为。
Intracerebroventricular oxytocin administration to virgin female rats that had been ovariectomized and primed with estrogen 48 h previously induced a rapid onset of full maternal behavior. The maternal behavior persisted and its incidence was dose-related. Tocinoic acid, the ring structure of oxytocin, also rapidly induced the onset of persistent, full maternal behavior. Arginine vasopressin induced persistent maternal behavior, but this behavior had a later onset. Prostaglandin[PG]F2.alpha. induced strong partial maternal behavior, which showed early onset but did not persist. Many other peptides, ovarian steroids, and PGE2 were no more effective than saline. The release of oxytocin and PGF2.alpha. during labor may promote maternal behavior in rats.