Experimental drug-induced changes in renal function and biodistribution of 99mTc-MDP.
Experimental drug-induced changes in renal function and biodistribution of 99mTc-MDP.
复制标题
实验药物诱导的肾功能变化和 99mTc-MDP 的生物分布。
DOI：
10.1097/00004424-198309000-00013
复制
发表时间：
1983
影响因子：
6.7
通讯作者：
Jones,D
中科院分区：
文献类型：
--
作者：
McAfee,JG;Singh,A;Roskopf,M;Ritter,C;Lyons,B;Schoonmaker,JE;Thomas,FD;Jones,D
分别给予甲氨蝶呤、长春新碱或庆大霉素后，大鼠肾摄取99 mTc亚甲基二磷酸盐（MDP）不规则增加。顺铂有规律地诱导剂量相关的MDP摄取增加，其与组织学上的肾小管损伤程度相关。MDP肾摄取增加并不总是伴随着同时注射I-131马尿酸的清除率降低，特别是在较低的药物剂量水平下。这一观察结果与先前的证据一致，即二膦酸盐和有机酸（如马尿酸）的肾小管转运机制不同。在较高剂量水平下，MDP摄取增加伴有肾钙升高、低磷酸盐血症、血清尿素氮和肌酐升高，仅偶尔出现轻度高钙血症。观察到的MDP肾摄取增加的幅度不能用铁代谢的改变或脱水来解释。药物引起的MDP肾潴留是正常的2倍或更多，似乎是一个有用的指标肾小管损伤时，其他。肾功能参数有时正常。
Increased renal uptake of 99m Tc methylene diphosphonate (MDP) was observed irregularly in rats after methotrexate, vincristine or gentamicin, administered separately. Cisplatin regularly induced a dose-related increased MDP uptake which correlated with the degree of tubular damage histologically. The augmented MDP renal uptake was not consistently accompanied by a decreased clearance of simultaneously injected I-131 Hippuran, particularly at lower drug dose levels. This observation agreed with previous evidence that the mechanisms of tubular transport of diphosphonates and organic acids like Hippuran are different. At higher dose levels, the augmented MDP uptake was accompanied by increased renal calcium, hypophosphatemia, elevated serum urea nitrogen and creatinine, and only occasional, mild hypercalcemia. The magnitude of the increased renal uptake of MDP observed could not be explained by alterations in iron metabolism or by dehydration. Drug-induced renal retention of MDP by a factor of 2 or more above normal appears to be a useful indicator of tubular damage when other. parameters of renal function are sometimes normal.