Lifestyle intervention in overweight individuals with a family history of diabetes
Lifestyle intervention in overweight individuals with a family history of diabetes
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DOI：
10.2337/diacare.21.3.350
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发表时间：
1998-03-01
期刊：
影响因子：
16.2
通讯作者：
Lang, W
中科院分区：
文献类型：
--
作者：
Wing, RR;Venditti, E;Lang, W
目的-为了评估超过2年的生活方式干预的影响，在v.斗争的变化，冠心病（CHD）的危险因素，和糖尿病的发病率在ol超重的个人与父母的糖尿病historyofdiabetes.Research设计和方法-参与者（n = 154），谁是30-100%超过理想体重，有一个或两个父母患有糖尿病。并且目前无糖尿病，被随机分配到为期2年的治疗，重点是饮食（减少热量和脂肪摄入），运动（目标为1，500千卡/周的适度活动），或饮食加运动的组合，或无治疗对照组。受试者在6个月，1年，2 years.RESULTS重新评估-在6个月时，饮食，运动和健身的措施组显着不同;饮食和饮食加运动组的体重减轻显着大于运动和控制条件。体重减轻与冠心病危险因素的积极变化相关。6个月后，行为和生理变化逐渐恶化，因此在2年时，几乎没有组间差异。两组之间发生糖尿病风险的差异具有临界显著性（P = 0.08）。最强的预测因素是基线时的糖耐量受损，这与糖尿病的发生风险呈正相关，而从基线到2年的体重减轻，这是负相关的，在所有治疗组中，4.5公斤的适度体重减轻与无体重减轻相比，可将2型糖尿病的风险降低30%。这里研究的干预措施在产生行为、体重或生理参数的长期变化方面无效。然而，从0到2年的损失减少了患2型糖尿病的风险。由于适度的体重减轻显著降低了患2型糖尿病的风险，因此需要进一步的研究来确定如何最好地增加至少达到适度体重减轻的受试者的百分比。
OBJECTIVE- To assess the effect of lifestyle intervention over 2 years on changes in v. fight, coronary heart disease (CHD) risk factors, and incidence of diabetes in ol overweight individuals with a parental history of diabetes.RESEARCH DESIGN AND METHODS- Participants (n = 154), who were 30-100% over ideal body weight, had one or both parents with diabetes. and were currently nondiabetic, were randomly assigned to 2-year treatments focused on diet (decreasing calories and fat intake), exercise (goal of 1,500 kcal/week of moderate activity), or the combination of diet plus exercise or to a no-treatment control group. Subjects were reassessed at 6 months, 1 year, and 2 years.RESULTS- At 6 months, the groups differed significantly on measures of eating, exercise, and fitness; weight losses in the diet and diet-plus-exercise groups were significantly greater than in the exercise and control conditions. Weight losses were associated with positive changes in CHD risk factors. After 6 months, there was gradual deterioration of behavioral and physiological changes, so that at 2 years, almost no between-group differences were maintained. Differences between groups in risk of developing diabetes were of borderline significance (P = 0.08). Strongest predictors were impaired glucose tolerance at baseline, which was positively related to risk of developing diabetes, and weight loss from baseline to 2 years, which was negatively related, in all treatment groups, a modest weight loss of 4.5 kg reduced the risk of type diabetes by similar to 30% compared with no weight loss.CONCLUSIONS- Although initially successful. the interventions studied here were not effective in producing long-term changes in behavior, weight, or physiological parameters. However n eight loss from 0 to 2 years reduced the risk of developing type 2 diabetes. Since modest weight loss significantly reduced risk of ripe 2 diabetes, further research is needed to determine how best to increase the percentage of subjects achieving at if ast a modest weight loss.