Degradation of the long-resistant pharmaceutical compounds carbamazepine and diatrizoate using mixed microbial culture
Degradation of the long-resistant pharmaceutical compounds carbamazepine and diatrizoate using mixed microbial culture
复制标题
DOI：
10.1080/10934529.2015.1128712
复制
发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Hun Ha;B. Mahanty;S. Yoon;Chang-gyun Kim
中科院分区：
文献类型：
--
作者：
Hun Ha;B. Mahanty;S. Yoon;Chang-gyun Kim
摘要通过实验室间歇实验，研究了卡马西平(CBZ)和泛影葡胺(DTZ)两种难降解药物的微生物降解。我们使用了一种明确的混合微生物培养方法，其中包括四种不同的微生物物种，这些微生物物种以前已知对顽固物质具有很高的分解能力。在液体培养中对CBZ或DTZ或两者的组合进行生物分解，为期12天。在初始浓度为100ug L−1的条件下，DTZ和CBZ的初始降解率分别为43.2%和60%。然而，最终的累积去除效率非常相似。溶解性有机碳(DOC)的去除程度与药物的降解程度相关。
ABSTRACT The microbial degradation of two recalcitrant pharmaceutical compounds, carbamazepine (CBZ) and diatrizoate (DTZ), was studied in laboratory batch experiments. We used a defined mixed microbial culture comprising four distinct microbial species that were previously known to have high decomposition capacity toward recalcitrant substances. Biological decomposition in liquid phase cultures for either CBZ or DTZ, or in a combination of the two, was conducted for 12 days. DTZ and CBZ were degraded by 43.2% and 60%, respectively from an initial concentration of 100 µg L−1. When degradation was assessed using a mixture of the two compounds, the initial degradation rates of CBZ and DTZ were lower than those observed in the single-compound study. However, the final cumulative removal efficiency was very similar. The extent of dissolved organic carbon (DOC) removal was correlated with the degradation of the pharmaceuticals.