Spontaneous baroreflex sensitivity in (pre)adolescents
Spontaneous baroreflex sensitivity in (pre)adolescents
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DOI：
10.1097/01.hjh.0000200517.27356.47
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发表时间：
2006-02-01
影响因子：
4.9
通讯作者：
Rosmalen, JGM
中科院分区：
文献类型：
--
作者：
Dietrich, A;Riese, H;Rosmalen, JGM
目的探讨青春期前青少年自发压力反射敏感性（BRS）的正常值，并探讨姿势、性别、年龄、青春期阶段、体重指数（BMI）和体力活动水平对BRS的影响。BRS是一个敏感的措施，交感神经和副交感神经的心血管调节，可能有助于检测早期亚临床自主神经功能障碍。设计一个横断面队列研究，在一个大样本的10-13岁的荷兰（前）青少年从一般population.Methods短期自发BRS确定非侵入性Portapres在仰卧位和站立位。使用离散傅立叶方法（频带0.07-0.14 Hz）通过功率谱分析计算BRS。结果立位时BRS为9.0 ± 4.9 ms/mmHg，仰卧位时为15.3 ± 9.1 ms/mmHg，两组比较差异有显著性（t = 27.8，P < 0.001）。在两种姿势下，女孩的BRS值均低于男孩（仰卧位14.3 +/- 8.7 vs 16.4 +/- 9.4 ms/mmHg，β = 0.12，P < 0.001;站立位8.4 +/- 4.4 vs 9.5 +/- 5.4 ms/mmHg，β = 0.08，P = 0.012），与年龄、青春期阶段、BMI和体力活动无关。女孩仰卧位和站立位正常BRS值的下限（P2.5）分别为3.6和2.2 ms/mmHg，男孩分别为3.9和2.5 ms/mmHg。站立位BRS随年龄增长而下降（β =-0.13，P < 0.001）。肥胖（前）青少年BMI与站立位BRS呈负相关（Kendall 'stau =-0.26，P = 0.010）。肥胖（前）青少年的BRS降低可能是未来心血管健康的候选预测因素，因此值得进一步探索。
Objective To present normal spontaneous baroreflex sensitivity (BRS) values and investigate the influence of posture, sex, age, pubertal stage, body mass index (BMI), , and physical activity level on BRS in (pre)adolescents. BRS is a sensitive measure of both sympathetic and parasympathetic cardiovascular regulation that may help detect early subclinical autonomic dysfunction.Design A cross-sectional cohort study in a large sample of 10-13-year-old Dutch (pre)adolescents from the general population.Methods Short-term spontaneous BRS was determined non-invasively by Portapres in both the supine and standing position. BRS was calculated by power spectral analysis using the discrete Fourier method (frequency band 0.07-0.14 Hz). Univariate statistical methods and multiple regression analyses were applied.Results BRS in a standing position was lower than in a supine position (9.0 +/- 4.9 versus 15.3 +/- 9.1 ms/mmHg; t = 27.8, P < 0.001). Girls had lower BRS values than boys in both postures (supine 14.3 +/- 8.7 versus 16.4 +/- 9.4 ms/mmHg, beta = 0.12, P < 0.001; standing 8.4 +/- 4.4 versus 9.5 +/- 5.4 ms/mmHg, beta = 0.08, P = 0.012), independent of age, pubertal stage, BMI, and physical activity. Lower limits (P2.5) for normal BRS values in supine and standing positions were for girls 3.6 and 2.2 ms/mmHg and for boys 3.9 and 2.5 ms/mmHg, respectively. BRS declined with age in the standing position (beta = -0.13, P < 0.001). In obese (pre)adolescents, BMI was negatively associated with BRS during standing (Kendall's tau = -0.26, P = 0.010).Conclusion The BRS of (pre)adolescents was negatively related to female sex, age, and obesity. A reduced BRS in obese (pre)adolescents might be a candidate predictor of future cardiovascular health, and therefore warrants further exploration.