Antamanide. Relaxation study of conformational equilibria.
Antamanide. Relaxation study of conformational equilibria.
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安塔马尼德。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
R. Winkler
中科院分区：
文献类型：
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作者：
W. Burgermeister;T. Wieland;R. Winkler
在0.5-100 MHz的频率范围内，测定了安他酰胺在不同溶剂中的超声吸收。三个弛豫效应可以解决，每一个发生在一个给定的频率保持不变的不同的溶剂。最慢的影响消失后，Na+络合物的形成。这归因于肽骨架的构象转变。这种效应的速率常数在106 s−1的范围内。另外两种弛豫效应可能是由氨基酸侧链的旋转异构引起的。的结构构象的溶剂依赖性进行了讨论。
Ultrasonic absorption of antamanide in different solvents was measured in the frequency range of 0.5–100 MHz. Three relaxation effects could be resolved, each occurring at a given frequency which remains unchanged for the different solvents. The slowest effect disappears upon Na+-complex formation. It is ascribed to a conformational transition of the peptide backbone. Rate constants of this effect are in the range of 106 s−1. The two other relaxation effects may be caused by rotational isomerism of amino-acid side chains. The solvent dependence of the structural conformations is discussed.