Characterization of parylene C as an encapsulation material for implanted neural prostheses
Characterization of parylene C as an encapsulation material for implanted neural prostheses
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DOI：
10.1002/jbm.b.31584
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发表时间：
2010-04-01
影响因子：
3.4
通讯作者：
Stieglitz, Thomas
中科院分区：
文献类型：
--
作者：
Hassler, Christina;von Metzen, Rene P.;Stieglitz, Thomas
聚对二甲苯C作为植入式神经假体的封装材料的适用性进行了表征和优化。测试了Parylene C在神经假体常用的不同基底材料上的粘附性，并研究了不同粘附促进方法的效率。在Si 3 N4、铂和聚对二甲苯C的第一膜上，用硅烷A-174实现了令人满意的粘附，其甚至经受住标准蒸汽灭菌。用所测试的方法不能充分改善对金和聚酰亚胺的粘附。此外，对未处理的、蒸汽灭菌的和退火的聚对二甲苯C层进行拉伸试验和结晶度测量，以研究热处理的影响。由于聚对二甲苯层中结晶部分的增加，这导致薄膜更脆、更硬。最后，使用电化学阻抗谱来测试聚对二甲苯C层是否能够保护Si 3 N4基底上的金属结构免受腐蚀。结果表明，这只能通过用硅烷A-174处理基材来实现。为了获得具有良好封装性能的聚对二甲苯C层，重要的是考虑神经假体中使用的材料，以找到最适合的工艺参数。(C)2010 Wiley Periodicals，Inc.生物医学材料研究杂志B部分：应用生物材料93 B：266-274，2010年
The applicability of parylene C as an encapsulation material for implanted neural prostheses was characterized and optimized. The adhesion of parylene C was tested on different substrate materials, which were commonly used in neural prostheses and the efficiency of different adhesion promotion methods was investigated. On Si3N4, platinum, and on a first film of parylene C, a satisfactory adhesion was achieved with Silane A-174, which even withstood standard steam sterilization. The adhesion to gold and polyimide could not be improved sufficiently with the tested methods. Furthermore, tensile tests and measurements of the degree of crystallinity were performed on untreated, on steam sterilized, and on annealed parylene C layers to investigate the influence of thermal treatment. This led to more brittle and stiffer films due to an increase in the crystalline portion in the parylene layers. Finally, an electrochemical impedance spectroscopy was used to test if a parylene C layer was able to protect a metallic structure against corrosion on a Si3N4 substrate. The results indicated that this could be only possible by treating the substrate with Silane A-174. To receive parylene C layers with a good encapsulation performance, it is important to consider the materials, which are used in the neural prosthesis, to find the best suited process parameters. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 93B: 266-274, 2010