Applying knowledge-anchored hypothesis discovery methods to advance clinical and translational research: the OAMiner project.
Applying knowledge-anchored hypothesis discovery methods to advance clinical and translational research: the OAMiner project.
复制标题
应用知识锚定的假设发现方法来推进临床和转化研究：OAMiner 项目。
DOI：
10.1136/amiajnl-2011-000736
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Gurcan,MetinN
中科院分区：
文献类型：
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作者：
Payne,PhilipRO;Jackson,RebeccaD;Best,ThomasM;Borlawsky,TaraB;Lai,AlbertM;James,Stephen;Gurcan,MetinN
The conduct of clinical and translational research regularly involves the use of a variety of heterogeneous and large-scale data resources. Scalable methods for the integrative analysis of such resources, particularly when attempting to leverage computable domain knowledge in order to generate actionable hypotheses in a high-throughput manner, remain an open area of research. In this report, we describe both a generalizable design pattern for such integrative knowledge-anchored hypothesis discovery operations and our experience in applying that design pattern in the experimental context of a set of driving research questions related to the publicly available Osteoarthritis Initiative data repository. We believe that this ‘test bed’ project and the lessons learned during its execution are both generalizable and representative of common clinical and translational research paradigms.
