Tracheostomy for long-term laryngeal experimentation
Tracheostomy for long-term laryngeal experimentation
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DOI：
10.1016/s0194-5998(98)70318-3
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发表时间：
1998-03-01
影响因子：
3.4
通讯作者：
Paniello, RC
中科院分区：
文献类型：
--
作者：
Dahm, JD;Paniello, RC
为了进行涉及长期存活手术的喉部研究，永久的气管切开术通常是必要的，对于使用长期诱导犬发声模型的实验，我们需要将气管切开术放置在尽可能低的位置，以最大限度地扩大吻合口上方的声门下空间，理想的实验性气管切开术也将是安全和容易执行的，不需要气管切开导管，并且维护成本低，需要最少的清洁或抽吸。在已发表的方法的基础上，对37只犬进行了气管切开术，如果将吻合口放置在气管第十二环以下，围手术期死亡率为57%，因为气管扭曲和随后的呼吸道阻塞，当气管切开术在该水平以上时，死亡率降至3%。为了实现这一改进，在技术上进行了许多重大改进，导致最后12只狗没有并发症。其中几个气管切开术维持了18个月以上，所得到的方法符合上述理想的实验性气管切开术的标准，也满足了我们对长期诱导发声模型的需要。
To perform laryngeal research involving long-term survival surgery, a permanent tracheostomy is often necessary, For experiments using a long-term induced canine phonation model, we required a tracheostomy that was placed as low as possible, to maximize the subglottic space superior to the stoma, The ideal experimental tracheostomy would also be safe and easy to perform, require no tracheostomy tube, and be low maintenance, requiring minimal cleaning or suctioning. Tracheostomies were performed in 37 dogs based on previously published methods, If the stoma was placed below the twelfth tracheal ring, the perioperative mortality rate was 57% because of kinking of the trachea and subsequent airway obstruction, When the tracheostomy was performed above this level, the mortality rate was reduced to 3%. A number of significant modifications in technique were made to achieve this improvement and resulted in the last 12 dogs having no complications. Several of the tracheostomies were maintained for more than 18 months, The method derived meets the above criteria for the ideal experimental tracheostomy and also meets our needs for a long-term induced phonation model.