Serum interleukin-6 and C-reactive protein are markedly elevated in acute decompensated heart failure patients with left ventricular systolic dysfunction
Serum interleukin-6 and C-reactive protein are markedly elevated in acute decompensated heart failure patients with left ventricular systolic dysfunction
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DOI：
10.1016/j.cyto.2009.11.006
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发表时间：
2010-03-01
期刊：
影响因子：
3.8
通讯作者：
Masuyama, Tohru
中科院分区：
文献类型：
--
作者：
Matsumoto, Mika;Tsujino, Takeshi;Masuyama, Tohru
细胞因子在心力衰竭（HF）中起重要作用。我们研究了急性失代偿性心力衰竭（ADHF）患者左室收缩功能障碍（LVSDF）和左室射血功能保留（PLVEF）患者的细胞因子水平是否不同。我们研究了81例因急性失代偿而入院的HF患者。将患者分为左室射血分数（LVEF）< 45%和左室射血分数（LVEF）≥ 45%两组。分别于入院时和出院时检测血清白细胞介素6（IL-6）、高敏C反应蛋白（hsCRP）、肿瘤坏死因子α（TNF-α）、IL-18和血浆脑钠肽（BNP）水平。入院时。LVSDF组IL-6和hsCRP水平高于PLVEF组。LVSDF治疗后IL-6和hsCRP降低，但PLVEF未降低，而两种HF治疗后血浆BNP水平均降低。TNF-α或IL-18水平在LVSDF和PLVEF之间没有差异，并且在两组中治疗后也没有变化。总之，LVSDF和PLVEF患者的ADHF细胞因子谱不同。IL-6-hsCRP通路的激活可能在ADHF合并LVSDF中发挥特异性作用。(C)2009爱思唯尔有限公司版权所有。
Cytokines play important roles in heart failure (HF). We examined whether cytokine levels are different in acute decompensated heart failure (ADHF) patients between with left ventricular systolic dysfunction (LVSDF) and with preserved LV ejection function (PLVEF). We studied 81 HF patients who were admitted to our hospital with acute decompensation. They were divided into two groups: LVSDF (LVEF) < 45% and PLVEF (LVEF >= 45%). Serum interleukin-6 (IL-6), highly sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-alpha), and IL-18 and plasma brain natriuretic peptide (BNP) were measured on admission and at discharge. On admission. IL-6 and hsCRP were higher in LVSDF than in PLVEF. IL-6 and hsCRP decreased after treatment in LVSDF, but not in PLVEF, while plasma BNP levels decreased in both HF with treatment. There was no difference in TNF-alpha or in IL-18 level between LVSDF and PLVEF, and they did not change after treatment in either group. In conclusion, cytokine profiles were different in ADHF between those with LVSDF and PLVEF. Activation of IL-6-hsCRP pathway may play a specific role in ADHF with LVSDF. (C) 2009 Elsevier Ltd. All rights reserved.