The viral oncoprotein HBx of Hepatitis B virus promotes the growth of hepatocellular carcinoma through cooperating with the cellular oncoprotein RMP.
The viral oncoprotein HBx of Hepatitis B virus promotes the growth of hepatocellular carcinoma through cooperating with the cellular oncoprotein RMP.
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DOI：
10.7150/ijbs.10275
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发表时间：
2014
影响因子：
9.2
通讯作者：
Wei W
中科院分区：
文献类型：
--
作者：
Wang Q;Xu Y;Zhou W;Zhong L;Wen Z;Yu H;Chen S;Shen J;Chen H;She Q;Jiang J;Miao J;Wei W
B肝炎病毒（HBV）最小的基因HBx被认为是肝癌发生过程中重要的病毒癌基因（V癌基因）。我们的前期工作证明RMP是肝细胞癌（HCC）细胞增殖所必需的细胞癌基因（C-癌基因）。在此，我们提出了V-癌基因HBx和C-癌基因RMP之间的合作，在肝癌的发展。HBx与RMP共表达可协同抑制肝癌细胞的增殖和凋亡。在体内，RMP的过表达加速了HBx诱导的裸鼠异种移植瘤的生长，反之亦然，HBx促进了RMP驱动的异种移植瘤的生长。虽然HBx不调控RMP的表达，但二者在肝癌细胞中存在相互作用，并共定位于细胞质中。HBx和RMP协同抑制凋亡因子的表达，促进抗凋亡因子的表达。这一发现表明，HBV可能通过其V-癌蛋白HBx与C-癌蛋白RMP相互作用诱导或至少部分促进HCC的发生。
The smallest gene HBx of Hepatitis B virus (HBV) is recognized as an important viral oncogene (V-oncogene) in the hepatocarcinogenesis. Our previous work demonstrated that RMP is a cellular oncogene (C-oncogene) required for the proliferation of hepatocellular carcinoma (HCC) cells. Here we presented the collaboration between V-oncogene HBx and C-oncogene RMP in the development of HCC. The coexpression of HBx and RMP resulted in the cooperative effect of antiapoptosis and proliferation of HCC cells. In vivo, overexpression of RMP accelerated the growth of HBx-induced xenograft tumors in nude mice and vice versa HBx promoted the growth of RMP-driven xenograft tumors. Although HBx didn't regulate the expression of RMP, HBx and RMP interact with each other and collocalized in the cytoplasm of HCC cells. HBx and RMP collaboratively inhibited the expression of apoptotic factors and promoted the expression of antiapoptotic factors. This finding suggests that HBV may induce, or at least partially contributes to the carcinogenesis of HCC, through its V-oncoprotein HBx interacting with the C-oncoprotein RMP.
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影响因子：
4.5
作者：
Mirón-García MC;Garrido-Godino AI;García-Molinero V;Hernández-Torres F;Rodríguez-Navarro S;Navarro F
通讯作者：
Navarro F
影响因子：
5.3
作者：
Yart, A;Gstaiger, M;Krek, W
通讯作者：
Krek, W
影响因子：
5.4
作者：
Kim, Sujeong;Kim, Hye-Young;Cho, Hyeseong
通讯作者：
Cho, Hyeseong
影响因子：
10.5
作者：
WOYCHIK, NA;LIAO, SM;YOUNG, RA
通讯作者：
YOUNG, RA
影响因子：
5.4
作者：
LEE, TH;ELLEDGE, SJ;BUTEL, JS
通讯作者：
BUTEL, JS