Synaptic properties of thalamic input to the subgranular layers of primary somatosensory and auditory cortices in the mouse.
Synaptic properties of thalamic input to the subgranular layers of primary somatosensory and auditory cortices in the mouse.
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DOI：
10.1523/jneurosci.1565-11.2011
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发表时间：
2011-09-07
期刊：
影响因子：
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通讯作者：
Sherman SM
中科院分区：
文献类型：
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作者：
Viaene AN;Petrof I;Sherman SM
突触输入的分类是理解大脑回路的重要组成部分。在本研究中，我们研究了小鼠丘脑皮层切片中初级体感（S1）和听觉（A1）皮层5a，5b和6层锥体神经元的丘脑输入的突触特性。刺激腹后内侧核（VPM）和腹侧分裂的内侧膝状体（MGBV）导致三个不同的反应类，其中两个从来没有被描述之前在丘脑皮质的预测。1A类反应包括突触抑制和全或无反应，而1B类反应表现出突触抑制和分级反应。1C类反应的特点是混合易化和抑郁以及分级反应。在任何反应类别中均未观察到代谢型谷氨酸受体的激活。我们的结论是，1类反应可以分为三个不同的子类，丘脑输入到皮层的颗粒下层可能与其他，皮质内输入联合收割机，以驱动其突触后靶细胞。我们也整合这些结果与我们最近的，类似的研究丘脑皮质输入颗粒和颗粒上层。
The classification of synaptic inputs is an essential part of understanding brain circuitry. In the present study, we examined the synaptic properties of thalamic inputs to pyramidal neurons in layers 5a, 5b, and 6 of primary somatosensory (S1) and auditory (A1) cortices in mouse thalamocortical slices. Stimulation of the ventral posterior medial nucleus (VPM) and the ventral division of the medial geniculate body (MGBv) resulted in three distinct response classes, two of which have never been described before in thalamocortical projections. Class 1A responses included synaptic depression and all-or-none responses while Class 1B responses exhibited synaptic depression and graded responses. Class 1C responses are characterized by mixed facilitation and depression as well as graded responses. Activation of metabotropic glutamate receptors was not observed in any of the response classes. We conclude that Class 1 responses can be broken up into three distinct subclasses, and that thalamic inputs to the subgranular layers of cortex may combine with other, intracortical inputs to drive their postsynaptic target cells. We also integrate these results with our recent, analogous study of thalamocortical inputs to granular and supragranular layers.