Potential Dopamine-1 Receptor Stimulation in Hypertension Management
Potential Dopamine-1 Receptor Stimulation in Hypertension Management
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DOI：
10.1007/s11906-011-0211-1
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发表时间：
2011-08-01
影响因子：
5.6
通讯作者：
Hussain, Tahir
中科院分区：
文献类型：
--
作者：
Asghar, Mohammad;Tayebati, Seyed K.;Hussain, Tahir
多巴胺受体在血压调节中的作用已得到充分证实。多巴胺D1样受体亚型（D1，D5）和D2样受体亚型（D2，D3，D4）的基因消融导致小鼠高血压表型。本文综述了多巴胺D1样受体亚型D1和D5（特别是D1受体），因为它们在调节钠稳态和血压中起着重要作用。主要描述肾脏多巴胺D1样受体的作用的研究包括在内，因为肾脏在维持钠稳态和血压的长期调节中起着关键作用。我们还试图描述D1样受体和其他蛋白质之间的相互作用，特别是血管紧张素II 1型和2型受体，参与维持钠稳态和血压。最后，我们讨论了一个新的概念，肾D1受体调节高血压，涉及氧化应激机制。
The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5) and D2-like receptor subtypes (D2, D3, D4) results in a hypertensive phenotype in mice. This review focuses on the dopamine D1-like receptor subtypes D1 and D5 (especially D1 receptors), as they play a major role in regulating sodium homeostasis and blood pressure. Studies mostly describing the role of renal dopamine D1-like receptors are included, as the kidneys play a pivotal role in the maintenance of sodium homeostasis and the long-term regulation of blood pressure. We also attempt to describe the interaction between D1-like receptors and other proteins, especially angiotensin II type 1 and type 2 receptors, which are involved in the maintenance of sodium homeostasis and blood pressure. Finally, we discuss a new concept of renal D1 receptor regulation in hypertension that involves oxidative stress mechanisms.