Permission to enter cell by shape: nanodisk vs nanosphere.
Permission to enter cell by shape: nanodisk vs nanosphere.
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DOI：
10.1021/am300840p
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发表时间：
2012-08
影响因子：
9.5
通讯作者：
Yi Zhang;Samuel Tekobo;Y. Tu;Qunfang Zhou;Xin Jin;S. A. Dergunov;E. Pinkhassik;B. Yan
中科院分区：
文献类型：
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作者：
Yi Zhang;Samuel Tekobo;Y. Tu;Qunfang Zhou;Xin Jin;S. A. Dergunov;E. Pinkhassik;B. Yan
Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.
