Prolonged morphine application modulates Bax and Hsp70 levels in primary rat neurons
Prolonged morphine application modulates Bax and Hsp70 levels in primary rat neurons
复制标题
延长吗啡应用可调节原代大鼠神经元中的 Bax 和 Hsp70 水平
DOI：
10.1016/j.neulet.2008.06.067
复制
发表时间：
2008-08
影响因子：
2.5
通讯作者：
Chen, Qiuyue
中科院分区：
文献类型：
--
作者：
Cui, Jia;Yu, Long-Chuan;Zhang, Yan;Chen, Qiuyue
Morphine has been used for pain treatment with a long history. Some data suggest that morphine is toxic to neurons and induces apoptosis, while other evidence shows that morphine could have beneficial effects against cell death. To determine how morphine affects pro-apoptotic protein Bax and molecular chaperone Hsp70, different concentrations of morphine were examined. Our results show that prolonged morphine administration for 5 days at 1μM concentration protects against serum deprivation induced cell death in rat primary neurons. Morphine treatment decreases Bax and Hsp70 levels in cultured rat primary neurons, suggesting morphine may have a protective role in staurosporine and serum deprivation induced cytotoxicity.
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DOI：
10.1097/00001503-200210000-00014
发表时间：
2002-10
期刊：
Current Opinion in Anaesthesiology
影响因子：
--
作者：
I. Gralow
通讯作者：
I. Gralow
DOI：
--
发表时间：
2001
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
H. Liu;B. C. McPherson;Z. Yao
通讯作者：
H. Liu;B. C. McPherson;Z. Yao
影响因子：
4.2
作者：
M. Razaq;Madelyn Balicas;N. Mankan
通讯作者：
M. Razaq;Madelyn Balicas;N. Mankan
影响因子：
6.1
作者：
J. Turchan-Cholewo;Yiling Liu;S. Gartner;Rollie Reid;C. Jie;Xuejun Peng;K. Chen;A. Chauhan;N. Haughey;R. Cutler;M. Mattson;C. Pardo;K. Conant;N. Sacktor;J. McArthur;K. Hauser;C. Gairola;A. Nath
通讯作者：
J. Turchan-Cholewo;Yiling Liu;S. Gartner;Rollie Reid;C. Jie;Xuejun Peng;K. Chen;A. Chauhan;N. Haughey;R. Cutler;M. Mattson;C. Pardo;K. Conant;N. Sacktor;J. McArthur;K. Hauser;C. Gairola;A. Nath
影响因子：
2.2
作者：
Atici, S;Cinel, L;Oral, U
通讯作者：
Oral, U