Plasma pyridoxal 5′-phosphate in the US population:: the National Health and Nutrition Examination Survey, 2003-2004
Plasma pyridoxal 5′-phosphate in the US population:: the National Health and Nutrition Examination Survey, 2003-2004
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DOI：
10.1093/ajcn/87.5.1446
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发表时间：
2008-05-01
影响因子：
7.1
通讯作者：
Selhub, Jacob
中科院分区：
文献类型：
--
作者：
Morris, Martha Savaria;Picciano, Mar Frances;Selhub, Jacob
背景：尚无大规模、以人群为基础的研究考虑使用血浆 5'-磷酸吡哆醛 (PLP) 来描述维生素 B-6 状态的描述性流行病学，PLP 是用于设定当前推荐膳食摄入量的维生素 B-6 充足性指标，在国家健康和营养检查调查（2003-2004 年）中，有 6000 名 1 岁以上的参与者，我们考虑了血浆 PLP 与各种维生素之间的关系。 研究人员对受试者特征进行了研究，并检查了血浆 PLP 和同型半胱氨酸随维生素 B-6 摄入量的变化趋势，包括整体和选定的亚组。结果：在男性中，仅在不补充维生素 B-6 的男性中，血浆 PLP 在青春期后随着年龄的增长而下降。无论补充剂使用情况如何，育龄女性的血浆 PLP 浓度均显着低于同龄男性，并且大多数口服避孕药使用者在所有亚组中维生素 B-6 摄入量为 2 至 2.9 毫克/天时，血浆 PLP 为 3%；在吸烟者、老年人、非西班牙裔黑人以及当前和以前口服避孕药使用者中，维生素 B-6 摄入量为 3 至 4.9 毫克/天时，血浆 PLP 为 3%。摄入量为 3 至 4.9 毫克/天
Background: No large-scale, population-based study has considered the descriptive epidemiology of vitamin B-6 status with use of plasma pyridoxal 5'-phosphate (PLP), the indicator of vitamin B-6 adequacy used to set the current Recommended Dietary Allowance, which is 6000 participants aged >= 1 y in the National Health and Nutrition Examination Survey (2003-2004), we considered relations between plasma PLP and various subject characteristics and examined trends in plasma PLP and homocysteine with vitamin B-6 intake, both overall and in selected subgroups.Results: In males, plasma PLP decreased with age after adolescence only in nonusers of supplemental vitamin B-6. Regardless of supplement use, plasma PLP concentrations of women of childbearing age were significantly lower than those of comparably aged men, and most oral contraceptive users had plasma PLP 3% at vitamin B-6 intakes from 2 to 2.9 mg/d in all subgroups and at intakes from 3 to 4.9 mg/d in smokers, the elderly, non-Hispanic blacks, and current and former oral contraceptive users. Intakes from 3 to 4.9 mg/d compared with