Decreased expression of osteopontin is related to tumor aggressiveness and clinical outcome of intrahepatic cholangiocarcinoma
Decreased expression of osteopontin is related to tumor aggressiveness and clinical outcome of intrahepatic cholangiocarcinoma
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DOI：
10.1111/j.1478-3231.2004.00886.x
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发表时间：
2004-02
影响因子：
6.7
通讯作者：
T. Terashi;S. Aishima;K. Taguchi;Y. Asayama;K. Sugimachi;S. Matsuura;M. Shimada;S. Maehara;Y. Maehara;M. Tsuneyoshi
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文献类型：
--
作者：
T. Terashi;S. Aishima;K. Taguchi;Y. Asayama;K. Sugimachi;S. Matsuura;M. Shimada;S. Maehara;Y. Maehara;M. Tsuneyoshi
背景：骨桥蛋白（Osteopontin， OPN）是一种分泌性黏附糖蛋白。最近的研究报道，在几种类型的人类癌症中，OPN的过表达与肿瘤发生、肿瘤侵袭性和不良预后有关。本研究的目的是确定OPN在肝内胆管癌（ICC）病例中的表达是否预示着临床结局。
Background: Osteopontin (OPN) is known to be a secreted adhesive glycoprotein. Recent studies have reported that the overexpression of OPN is correlated with tumorigenesis, tumor aggressiveness, and poor prognosis in several types of human cancer. The aim of this study was to determine whether the expression of OPN in cases of intrahepatic cholangiocarcinoma (ICC) indicates the clinical outcome.