An association between oxygen desaturation and D-dimer in patients with obstructive sleep apnea syndrome
An association between oxygen desaturation and D-dimer in patients with obstructive sleep apnea syndrome
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DOI：
10.1160/th05-02-0103
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发表时间：
2005-09-01
影响因子：
6.7
通讯作者：
Kramer, MR
中科院分区：
文献类型：
--
作者：
Shitrit, D;Peled, N;Kramer, MR
D-二聚体是纤维蛋白的降解产物，越来越多地被用作各种血栓性疾病的标志物和预后因子。以往的研究表明，阻塞性睡眠呼吸暂停与血小板活化和高凝状态有关。本研究的目的是评估血浆D-二聚体试验在阻塞性睡眠呼吸暂停患者中的潜在作用。我们设计了一个前瞻性的组比较研究，在三级保健，大学附属医疗中心。纳入了103例平均年龄为57岁（范围50-76岁），症状提示阻塞性睡眠呼吸暂停的患者。所有病例均行多导睡眠图检查，并采集血液，采用MiniQuant浊度法测定血浆D-二聚体。比较了正常和高（>250 ng/ml）D-二聚体水平患者的人口统计学和多导睡眠图数据。D-二聚体值较高的组平均最低血氧饱和度较低（72.1 +/- 16.4 vs. 81.7 +/-11.6%，p=0.008），平均血氧饱和度低于90%的时间较长（84.1 +/- 86.2 vs. 38.5 +/- 70.8分钟，p=0.032）。呼吸紊乱指数和睡眠结构与D-二聚体无相关性。我们的结论是，睡眠呼吸暂停综合征与纤溶活性。氧饱和度下降似乎是阻塞性睡眠呼吸暂停和高凝状态之间的联系的介导因素之一。
D-dimer, a degradation product of fibrin, is being increasingly used as a marker and prognostic factor in various thrombotic diseases. Previous reports have shown that obstructive sleep apnea is associated with platelet activation and hypercoagulability. The aim of the study was to assess the potential role of the plasma D-dimer test in patients with obstructive sleep apnea. We designed a prospective group comparison study in a tertiary-care, university-affiliated medical center. One hundred and three patients of mean age 57 years (range 50-76 years) with symptoms suggestive of obstructive sleep apnea were included. Polysomnography was performed in all cases, and blood was collected for plasma D-dimer measurement by MiniQuant turbid-metric assay. The demographic and polysomnograph data were compared between patients with normal and high (>250 ng/ml) D-dimer levels. The group with higher D-dimer values had lower mean minimal oxygen saturation (72.1 +/- 16.4 vs. 81.7 +/- 11.6%, p=0.008) and a longer mean period of oxygen saturation below 90% (84.1 +/- 86.2 vs. 38.5 +/- 70.8 minutes, p=0.032). There was no correlation of respiratory disturbance index and sleep architecture with D-dimer values. We concluded that sleep apnea syndrome is associated with fibrinolytic activity. Oxygen desaturation seems to be one of the mediatory factors in the putative connection between obstructive sleep apnea and hypercoagulability state.