Effect of temperature, pH, and corneal birefringence on polarimetric glucose monitoring in the eye
Effect of temperature, pH, and corneal birefringence on polarimetric glucose monitoring in the eye
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DOI：
10.1117/1.1484163
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发表时间：
2002-07-01
影响因子：
3.5
通讯作者：
Coté, GL
中科院分区：
文献类型：
--
作者：
Baba, JS;Cameron, BD;Coté, GL
在过去的二十年中，旋光测定法已被研究作为血糖监测的无创替代方案，以支持糖尿病患者。特别是，含有被称为房水的液体的眼睛前房由于其合理的光程（1厘米）、低散射和最小的去极化指数而被证实是偏振葡萄糖测量的最佳传感部位。从本质上讲，眼睛可以被认为是进入身体的光学窗口。在本文中，我们将首先介绍必须克服的关键挑战，使使用眼内偏振光成为一种可行的无创血糖监测方法，总结我们为此所做的工作，然后报告我们的最新研究，即温度、pH 和角膜双折射对我们的偏振血糖监测系统的影响。 (C) 2002 年光电仪器工程师协会。
Over the last two decades polarimetry has been investigated as a noninvasive alternative for glucose monitoring in support of diabetic patients. In particular, the anterior chamber of the eye containing the fluid known as the aqueous humor has been confirmed to be the optimal sensing site for polarimetric glucose measurements due to its reasonable pathlength (1 cm), low scatter, and minimal depolarization index. In essence, the eye can be thought of as an optical window into the body. In this paper, we will first introduce the key challenges that must be overcome to make the use of polarized light in the eye a viable method for noninvasive glucose monitoring, summarize our work toward this endeavor, and then report on our latest research, namely, the effect of temperature, pH, and corneal birefringence on our polarimetric glucose monitoring system. (C) 2002 Society of Photo-Optical Instrumentation Engineers.