Nucleating a Microtubule: Put a γ-Tubulin Ring on It.

Nucleating a Microtubule: Put a γ-Tubulin Ring on It.
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使微管成核:在其上放置一个 γ-微管蛋白环。

DOI:
10.1016/j.devcel.2020.05.018
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发表时间:
2020
期刊:
影响因子:
11.8
通讯作者:
Rice,LukeM
Rice,LukeM
中科院分区:
生物学1区
文献类型:
--
作者:
Gangadharan,Binnu;Rice,LukeM

文献摘要

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γ-微管蛋白环复合物(γTuRC)是一种微管成核剂,控制新微管形成的时间和位置。在这一期的《发育细胞》中,Consolati et al.通过确定人γTuRC的结构并对其活性进行定量测量,为γ TuRC介导的成核机制提供急需的见解。
The γ-tubulin ring complex (γTuRC) is a microtubule nucleator that controls when and where new microtubules form. In this issue ofDevelopmental Cell, Consolati et al. provide much-needed insight into the mechanism of γTuRC-mediated nucleation by determining the structure of human γTuRC and performing quantitative measurements of its activity.