Selective enhancement of spatial learning under chronic psychosocial stress
Selective enhancement of spatial learning under chronic psychosocial stress
复制标题
DOI：
10.1046/j.1460-9568.2002.02043.x
复制
发表时间：
2002-06-01
影响因子：
3.4
通讯作者：
Fuchs, E
中科院分区：
文献类型：
--
作者：
Bartolomucci, A;de Biurrun, G;Fuchs, E
海马体长期以来被证明与几种学习和记忆过程有关。海马作为边缘-下丘脑-垂体-肾上腺轴的一部分，在应激反应的调节中也起着积极的作用。长时间的应激暴露导致糖皮质激素水平长期升高，影响海马功能和结构，诱导学习和记忆改变，抑制成年齿状回细胞增殖。在这里，成年雄性树鼩（Tupaia belangeri）暴露于慢性心理社会压力进行了测试，反复使用两种不同的学习任务，旨在评估依赖于和独立的认知功能的holeboard装置。我们发现，慢性应激增强了动物的学习能力，而在非应激的任务中没有发现应激诱导的效果。此外，在五周的应激后，海马齿状回的细胞增殖减少。这些结果表明，特定的记忆过程不仅可能保持完整，但确实是促进慢性应激，尽管皮质醇水平升高和抑制海马细胞增殖。
The hippocampus has long been proved to be implicated in several learning and memory processes. Being integrated into the limbic-hypothalamus-pituitary-adrenal axis, the hippocampus also plays an active role in the regulation of the stress response. Long lasting elevated levels of glucocorticoids resulting from a prolonged stress exposure affect hippocampal functions and structure, inducing learning and memory alterations and suppressing cell proliferation in the adult dentate gyrus. Here, adult male tree shrews (Tupaia belangeri ) exposed to chronic psychosocial stress were tested repeatedly on a holeboard apparatus using two different learning tasks devised to evaluate hippocampal-dependent and hippocampal-independent cognitive function. We show that chronic stress enhanced learning in animals performing the hippocampal-dependent task, whereas no stress-induced effect was found in the hippocampal-independent task. Additionally, after five weeks of stress, cell proliferation was reduced in the hippocampal dentate gyrus. These results indicate that specific memory processes not only may remain intact, but indeed are facilitated by chronic stress, despite elevated cortisol levels and suppressed hippocampal cell proliferation.