The use of 2-deoxy-D-glucose for genital herpes.
The use of 2-deoxy-D-glucose for genital herpes.
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2-脱氧-D-葡萄糖用于治疗生殖器疱疹。
DOI：
10.1001/jama.1980.03300270017010
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
K. Holmes
中科院分区：
文献类型：
--
作者：
L. Corey;K. Holmes
致编辑。-关于Blough和Giuntoli（241:2798, 1979）使用2-脱氧-d -葡萄糖治疗生殖器单纯疱疹病毒（HSV）的研究方法和结果，我们有几个问题。尽管作者声称进行了一项双盲、安慰剂对照试验，但36名患者接受了2-脱氧-d -葡萄糖治疗，而出于“伦理原因”，只有15名患者接受了安慰剂治疗。是否采用了正式的随机化设计，是否与双盲研究设计相容？此外，在评估首次生殖器疱疹患者的病情时，必须通过血清学试验将真正的“原发性生殖器疱疹”患者分层，即首次接触HSV的患者和既往有过HSV 1型感染的患者，因为原发性生殖器疱疹患者的病毒脱落持续时间（平均13.0天）比既往有过HSV 1型感染的患者（平均7.5天）更长。
To the Editor.— We have several questions concerning the methods and results of the study by Blough and Giuntoli (241:2798, 1979) on the use of 2-deoxy-D-glucose in the treatment of genital herpes simplex virus (HSV). Although the authors claimed to have performed a double-blind, placebo-controlled trial, 36 patients received 2-deoxy-D-glucose, while for "ethical reasons" only 15 received the placebo therapy. Was a formal randomization design employed, and was this compatible with a double-blind study design? In addition, in evaluating the conditions of patients with first episodes of genital herpes, stratification by serological tests into those with true "primary genital herpes," ie, those who are experiencing their first exposure to HSV and those who have experienced prior HSV type 1 infection, must be performed, because patients with primary genital herpes experience a longer duration of viral shedding (mean, 13.0 days) than those with previous HSV type 1 infection (mean, 7.5 days).