Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky.
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky.
复制标题
小鼠视觉皮层颜色对抗反应类型的不对称分布支持卓越的天空色觉。
DOI：
10.1101/2023.06.01.543054
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tolias,AndreasS
中科院分区：
文献类型：
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作者：
Franke,Katrin;Cai,Chenchen;Ponder,Kayla;Fu,Jiakun;Sokoloski,Sacha;Berens,Philipp;Tolias,AndreasS
颜色是影响行为的重要视觉特征，并且已经在各种脊椎动物物种中研究了色觉的视网膜基础。虽然许多研究已经调查了灵长类动物视觉大脑区域中颜色信息是如何处理的，但我们对其他物种（包括大多数二色哺乳动物）的视网膜之外的颜色信息如何组织的了解有限。在这项研究中，我们系统地描述了小鼠初级视觉皮层 (V1) 中颜色的呈现方式。使用大规模神经元记录以及亮度和颜色噪声刺激，我们发现小鼠 V1 中超过三分之一的神经元在其感受野中心是颜色对立的，而感受野周围主要捕获亮度对比度。此外，我们发现颜色对立在编码天空的后 V1 中尤其明显，与小鼠经历的自然场景的统计数据相匹配。使用无监督聚类，我们证明了整个皮层颜色表示的不对称性可以通过上视野中表示的绿色打开/紫外线关闭颜色对手响应类型的不均匀分布来解释。最后，一个具有自然场景启发的参数刺激的简单模型表明，绿色开启/紫外线关闭颜色对手响应类型可以增强在嘈杂的日光场景中对“掠夺性”类暗紫外线物体的检测。这项研究的结果强调了小鼠视觉系统中颜色处理的相关性，并有助于我们理解颜色信息如何在跨物种的视觉层次结构中组织。
Color is an important visual feature that informs behavior, and the retinal basis for color vision has been studied across various vertebrate species. While many studies have investigated how color information is processed in visual brain areas of primate species, we have limited understanding of how it is organized beyond the retina in other species, including most dichromatic mammals. In this study, we systematically characterized how color is represented in the primary visual cortex (V1) of mice. Using large-scale neuronal recordings and a luminance and color noise stimulus, we found that more than a third of neurons in mouse V1 are color-opponent in their receptive field center, while the receptive field surround predominantly captures luminance contrast. Furthermore, we found that color-opponency is especially pronounced in posterior V1 that encodes the sky, matching the statistics of natural scenes experienced by mice. Using unsupervised clustering, we demonstrate that the asymmetry in color representations across cortex can be explained by an uneven distribution of green-On/UV-Off color-opponent response types that are represented in the upper visual field. Finally, a simple model with natural scene-inspired parametric stimuli shows that green-On/UV-Off color-opponent response types may enhance the detection of ‘predatory’-like dark UV-objects in noisy daylight scenes. The results from this study highlight the relevance of color processing in the mouse visual system and contribute to our understanding of how color information is organized in the visual hierarchy across species.