Association of polymyalgia rheumatica and giant-cell arteritis with HLA-B8.
Association of polymyalgia rheumatica and giant-cell arteritis with HLA-B8.
复制标题
风湿性多肌痛和巨细胞动脉炎与 HLA-B8 的关联。
DOI：
10.1136/bmj.2.6093.989
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发表时间：
1977
影响因子：
--
通讯作者：
D. Voak
中科院分区：
文献类型：
--
作者：
B. Hazleman;A. Goldstone;D. Voak
本文对30例颞动脉炎、27例风湿性多肌痛和216例正常献血员进行了组织相容性抗原检测。HLA-B8在风湿性多肌痛（59%）和颞动脉炎（50%）患者中明显高于对照组（27%）。风湿性多肌痛患者中HLA-A10阳性率为26%，而对照组仅为10%，这可能与该疾病的免疫发病机制有关。
Histocompatibility antigens were determined in 30 patients with temporal arteritis, 27 patients with polymyalgia rheumatica, and 216 normal blood donors. HLA-B8 was significantly more common in patients with polymyalgia rheumatica (59%) and temporal arteritis (50%) than in the controls (27%). The findings of HLA-A10 in 26% of the patients with polymyalgia rheumatica compared with only 10% of the controls may be associated with the suggested immunological pathogenesis of the condition.