COMPLEX SPIKES IN PURKINJE-CELLS IN THE LATERAL VERMIS (B-ZONE) OF THE CAT CEREBELLUM DURING LOCOMOTION
COMPLEX SPIKES IN PURKINJE-CELLS IN THE LATERAL VERMIS (B-ZONE) OF THE CAT CEREBELLUM DURING LOCOMOTION
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DOI：
10.1113/jphysiol.1987.sp016487
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发表时间：
1987-04-01
影响因子：
5.5
通讯作者：
ARMSTRONG, DM
中科院分区：
文献类型：
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作者：
ANDERSSON, G;ARMSTRONG, DM
1.在猫行走于移动带或水平梯上时，在小脑V小叶蚓部外侧部（即B区）的41个浦肯野细胞中记录到由攀爬纤维输入引起的复合峰电位（c.s.s）。大多数细胞位于组成小叶的叶尖附近，有些细胞逆行侵入同侧前庭外侧核。在所有细胞中，c.s.s可以通过手动递送到颈部和/或躯干和/或肢带和/或肢体的近端部分的机械刺激来诱发。2.在行走过程中，c.s.s的发生率在不同的细胞中从0.8到2.55/s不等（即大约2.5/s）。0.8 2/step）。当活动在许多连续步骤中平均时，c.s.在整个步骤循环中，发生率从来不是完全恒定的，但是在循环期间的任何精确固定的时间没有检测到C.S. S复发的趋势。3.当梯子运动受到干扰，因为一个梯级经历了一个意想不到的2厘米下降时，踩上，一些细胞产生了c.s.在一定比例的试验中出现短潜伏期。这种反应与梯级运动的开始时间很好地锁定在一起，但与梯级运动的停止时间却不一样（它们往往先于梯级运动）。4.对于任一前肢的扰动，最早的位移相关的c.s.发生在不同的细胞之间的40和64毫秒更快的梯级运动的开始。在不同的细胞中，c.s.s发生在五个扰动步骤中的一个到四个扰动步骤中的三个（平均约为2.5个）。五个步骤中的两个）。17个细胞中有8个对同侧前肢的扰动作出反应，10个细胞中有5个对对侧扰动作出反应。5.同侧后肢的扰动伴随着9个细胞中的4个细胞的c.s.s，潜伏期通常较长（约为2.5小时）。30-40 ms）。一个细胞显示出c.s.的概率降低。发生。对侧后肢扰动反应性的系统研究获得的数据不足。6.细胞表现出不同的模式的肢体特异性，响应一个，两个或所有的三个肢体研究的扰动。总的来说，在研究的20个细胞中，有13个细胞（65%）的c.s.s至少伴随一个肢体的扰动。7.研究结果进行了讨论的假设（Oscarsson，1980年），攀爬纤维产生的下橄榄神经元的脊髓橄榄小脑通路的继电器可能作为检测器的运动控制错误，包括预期和实现的运动之间的不匹配。结论是，结果是兼容的假设，但他们并没有证明其正确性。
1. Complex spikes (c.s.s) due to climbing fibre input were recorded from forty-one Purkinje cells in the lateral part of the vermis (i.e. the b zone) of lobule V of the cerebellum in cats walking on a moving belt or a horizontal ladder. Most cells were near the tips of the folia making up the lobule and some were shown by antidromic invasion to project to the ipsilateral lateral vestibular nucleus. In all cells c.s.s could be evoked through mechanical stimuli delivered manually to the neck and/or trunk and/or the limb girdles and/or the proximal parts of the limbs. 2. During walking c.s.s occurred at rates which ranged in different cells from 0.8 to 2.55/s (i.e. ca. 0.8 to 2/step). When activity was averaged across many successive steps the probability of c.s. occurrence was never completely constant throughout the step cycle, but no tendency was detected for c.s.s to recur at any precisely fixed time during the cycle. 3. When ladder locomotion was perturbed because a rung underwent an unexpected 2 cm descent when stepped on, some cells generated a c.s. at short latency in a proportion of trials. Such responses were well time-locked to the onset of rung movement but not to its cessation (which they often preceded). 4. For perturbations of either forelimb the earliest displacement-related c.s. occurred in different cells between 40 and 64 ms faster the onset of rung movement. In different cells c.s.s occurred in from one out of five to three out of four perturbed steps (mean ca. two out of five steps). Eight out of seventeen cells responded to perturbation of the forelimb ipsilateral to the cell and five out of ten responded to contralateral perturbations. 5. Perturbation of the ipsilateral hind limb was accompanied by c.s.s in four out of nine cells and latency was usually longer (by ca. 30-40 ms). One cell showed a decrease in the probability of c.s. occurrence. Insufficient data were obtained for a systematic study of responsiveness to perturbation of the contralateral hind limb. 6. Cells showed different patterns of limb specificity, responding to pertubation of one, two or all of the three limbs studied. In total, c.s.s accompanied perturbation of at least one limb in thirteen out of twenty cells studied (65%). 7. The findings are discussed in relation to the hypothesis (Oscarsson, 1980) that climbing fibres arising from inferior olivary neurones which are relays on spino-olivo-cerebellar pathways may function as detectors of motor control errors, including mismatches between intended and achieved movements. It is concluded that the results are compatible with the hypothesis, though they do not prove its correctness.