Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET) System.
Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET) System.
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DOI：
10.3390/s17051164
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发表时间：
2017-05-19
期刊：
影响因子：
--
通讯作者：
Wuest T
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文献类型：
--
作者：
Melroy S;Bauer C;McHugh M;Carden G;Stolin A;Majewski S;Brefczynski-Lewis J;Wuest T
全脑正电子发射断层扫描(PET)脑成像仪有几种应用，它被设计成一种可佩戴在患者头上的便携式单元。在探测器技术的改进下，一种轻便、高性能的设备将允许在不同的环境和行为任务期间进行PET脑成像。这样一种允许受试者移动头部和行走的可穿戴系统--动态微剂量PET(AM-PET)--目前正在开发中。该成像器将有助于测试执行手势、虚拟现实活动和行走等选定活动的受试者。对这类轻量级移动设备的需求导致了概念验证便携式头戴式设备的构建，该设备使用12个硅光电倍增管(SiPM)PET模块传感器构建在一个适合头部周围的小环中。本文主要研究AM-PET项目的机械支撑方面的工程设计，既包括现有的设备，也包括即将到来的下一代设备。这项工作的目标是优化扫描仪及其机械结构的设计，通过减少重量的影响来提高受试者的舒适性，并使其在不同研究活动中的应用多样化。
Several applications exist for a whole brain positron-emission tomography (PET) brain imager designed as a portable unit that can be worn on a patient’s head. Enabled by improvements in detector technology, a lightweight, high performance device would allow PET brain imaging in different environments and during behavioral tasks. Such a wearable system that allows the subjects to move their heads and walk—the Ambulatory Microdose PET (AM-PET)—is currently under development. This imager will be helpful for testing subjects performing selected activities such as gestures, virtual reality activities and walking. The need for this type of lightweight mobile device has led to the construction of a proof of concept portable head-worn unit that uses twelve silicon photomultiplier (SiPM) PET module sensors built into a small ring which fits around the head. This paper is focused on the engineering design of mechanical support aspects of the AM-PET project, both of the current device as well as of the coming next-generation devices. The goal of this work is to optimize design of the scanner and its mechanics to improve comfort for the subject by reducing the effect of weight, and to enable diversification of its applications amongst different research activities.