Neural correlates of levels of emotional awareness during trauma script-imagery in posttraumatic stress disorder
Neural correlates of levels of emotional awareness during trauma script-imagery in posttraumatic stress disorder
复制标题
DOI：
10.1097/psy.0b013e31815f66d4
复制
发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Lanius, Ruth
中科院分区：
文献类型：
--
作者：
Frewen, Paul;Lane, Richard D.;Lanius, Ruth
目的：研究创伤后应激障碍(PTSD)患者(n=25)和非创伤后应激障碍(n=16)患者的情绪意识水平差异，以此作为创伤后应激障碍(PTSD)患者血氧水平依赖(BOLD)反应的预测因子。方法：受试者完成情绪知觉水平量表(LEAS)和功能磁共振成像创伤脚本驱动的表象范式。结果：创伤后应激障碍患者的LEAS评分低于对照组。健康对照组的LEAS评分与创伤后腹前扣带回皮质(VACC)的BOLD活动呈正相关，而PTSD患者的LEAS评分与VACC的激活呈负相关。结论：创伤后应激障碍患者的情绪知觉水平低于平均水平。健康对照组与创伤后应激障碍患者相比，在创伤脚本驱动的想象中，情绪意识水平与VACC反应存在差异。
Objective: To examine individual differences in levels of emotional awareness as a predictor of the blood oxygenation level dependent (BOLD) response to trauma script-driven imagery in trauma-exposed individuals with (n = 25) and without (n = 16) posttraumatic stress disorder (PTSD). Methods: Participants completed the Levels of Emotional Awareness Scale (LEAS) and a functional magnetic resonance imaging trauma script-driven imagery paradigm. Results: Patients with PTSD exhibited lower LEAS scores in comparison with the control group. LEAS scores correlated positively with BOLD activity during trauma script-imagery in the ventral anterior cingulate cortex (vACC) in healthy controls, whereas LEAS scores correlated negatively with activation of vACC in individuals with PTSD. Conclusion: Patients with PTSD exhibit lower than average levels of emotional awareness. Levels of emotional awareness are differentially associated with vACC response during trauma script-driven imagery in healthy controls versus individuals with PTSD.