The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end.
The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end.
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小鼠中的 L1Md 长散布重复序列家族：几乎所有示例都在一端被截断。
DOI：
10.1093/nar/11.24.8847
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发表时间：
1983
影响因子：
14.9
通讯作者：
Edgell,MH
中科院分区：
文献类型：
--
作者：
Voliva,CF;Jahn,CL;Comer,MB;Hutchison3rd,CA;Edgell,MH
我们的特点是一个大的重复元件，已被发现在7个不同的位置内的β珠蛋白基因座的BALB/c小鼠。该重复序列具有不寻常的结构，因为每个不同的成员具有保守的元件的相同末端，而另一端终止于每个重复序列成员中的不同点。来自β珠蛋白基因座的重复序列内的序列与其它重复家族如MIF-1、Bam-5、R和BamH 1家族具有同源性。最近提出了（T。Fanning，（1983）Nucleic Acids Res.11，5073-5091）是具有我们在珠蛋白基因座中发现的相同组织的结构的一部分。从BALB/c的基因组文库中的珠蛋白基因座的重复序列衍生的探测斑块显示，几乎所有的重复从这个家庭的组织方式与建议的结构一致。
We have characterized a large repetitive element which has been found at seven different locations within the beta globin locus of the BALB/c mouse. This repeat has an unusual structure in that each of the different members has the same end of the element conserved while the other end terminates at a different point in each repeat member. The sequences within the repeats from the beta globin locus have homology with other repetitive families such as the MIF-1, Bam-5, R, and the BamHl families. These were recently proposed (T. Fanning, (1983) Nucleic Acids Res. 11, 5073–5091) to be part of a structure with the same organization which we found in the globin locus. Probing plaques from a BALB/c genomic library with sequences derived from the repeats in the globin locus shows that virtually all of the repeats from this family are organized in a manner consistent with the proposed structure.