Associations of serum adiponectin with markers of cardio-metabolic disease risk in Indigenous Australian adults with good health, diabetes and chronic kidney disease
Associations of serum adiponectin with markers of cardio-metabolic disease risk in Indigenous Australian adults with good health, diabetes and chronic kidney disease
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DOI：
10.1016/j.orcp.2015.11.008
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发表时间：
2016-11-01
影响因子：
4.3
通讯作者：
Maple-Brown, L. J.
中科院分区：
文献类型：
--
作者：
Hughes, J. T.;O'Dea, K.;Maple-Brown, L. J.
在女性中观察到的较高血清脂联素浓度通常归因于肥胖或性激素的差异。几乎没有数据描述澳大利亚土著居民的脂联素，也没有研究探讨其与心脏代谢疾病风险标志物和慢性肾脏疾病（CKD）的关系。目的：描述以社区为基础的澳大利亚土著成年人样本中血清脂联素与心脏代谢疾病风险标志物和肾功能的关系，特别是性别特异性差异。方法：对548名澳大利亚土著成年人社区志愿者样本的横断面分析（62%女性），分为5个心脏代谢风险组，从健康状况良好（第1层）到高心脏代谢风险和低测量肾小球滤过率（mGFR = 90）。当mGFR >= 60时，女性性别、HDL-胆固醇（阳性）、mGFR和腰臀比（WHR）（倒数）与脂联素对数独立相关;当mGFR < 60时，女性性别与脂联素对数降低0.27个单位相关。结论：在mGFR < 60 ml/min/1.73 m（2）的土著澳大利亚人中，女性性别与较高的脂联素浓度无关。高腰臀比在两种性别中都很常见，并且与脂联素呈负相关。需要进行纵向研究，以检查血清脂联素，肥胖和心血管疾病事件在土著澳大利亚人的关系。(C)2015年亚洲大洋洲肥胖研究协会。由爱思唯尔有限公司出版。保留所有权利。
The higher serum adiponectin concentrations observed in females are often attributed to differences in adiposity or sex hormones. There is little data describing adiponectin in Indigenous Australians, and no studies examining its association with cardio-metabolic disease risk markers and chronic kidney disease (CKD). Aim: To describe the relationship of serum adiponectin with cardio-metabolic disease risk markers and kidney function in a community-based sample of Indigenous Australian adults, with particular reference to sex-specific differences.Methods: A cross-sectional analysis of a community-based volunteer sample of 548 Indigenous Australian adults (62% female), stratified into five cardio-metabolic risk groups ranging from good health (strata-1) to high cardio-metabolic risk and low measured glomerular filtration rate (mGFR, = 90). Female-gender, HDL-cholesterol(positive), mGFR and waist: hip ratio (WHR) (inverse) were independently associated with log-adiponectin when mGFR >= 60; when mGFR < 60, female-gender was associated with 0.27 units lower log-adiponectin.Conclusion: Female-gender was not associated with higher adiponectin concentrations in Indigenous Australians with mGFR < 60 ml/min/1.73 m(2). High WHR was frequent in both genders, and inversely associated with adiponectin. Longitudinal studies are needed to examine relationships of serum adiponectin, obesity and cardiovascular disease events in Indigenous Australians. (C) 2015 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.