ULTRADIAN OSCILLATIONS IN PLASMA-RENIN ACTIVITY - THEIR RELATIONSHIPS TO MEALS AND SLEEP STAGES
ULTRADIAN OSCILLATIONS IN PLASMA-RENIN ACTIVITY - THEIR RELATIONSHIPS TO MEALS AND SLEEP STAGES
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DOI：
10.1210/jcem-61-2-280
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发表时间：
1985-01-01
影响因子：
5.8
通讯作者：
SCHIEBER, JP
中科院分区：
文献类型：
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作者：
BRANDENBERGER, G;FOLLENIUS, M;SCHIEBER, JP
在6名仰卧的正常受试者中研究了PRA [血浆肾素活性]的24小时模式;使用18个夜间曲线和伴随的睡眠多导记录分析了睡眠阶段和PRA振荡之间的关系。每隔10分钟采集一次血液。通过调整三次多项式的24小时的数据得到的缓慢的趋势是不可重复的个人之间，没有昼夜节律模式被检测到。PRA全天持续振荡。光谱分析表明，PRA在夜间以约100分钟的规律性周期振荡。这种周期性在白天的膳食摄入量，这诱导PRA峰值与大个体间的变化的大小进行了修改。夜间PRA振荡与快速眼动（REM）睡眠和非REM睡眠的交替有密切关系。非快速眼动睡眠总是与PRA水平的增加或峰值相一致。REM睡眠发生在PRA下降或最低点。更准确地说，PRA的增加标志着从REM睡眠到第二阶段的过渡，第三阶段和第四阶段通常发生在PRA最高的时候。PRA中的周期性夜间振荡与REM-非REM周期交替之间的这种关系可能在CNS中转化为类似的振荡过程，或者可能与睡眠期间的血液动力学变化有关，这可能部分受肾素-血管紧张素系统控制。
The 24 h pattern of PRA [plasma renin activity] was studied in 6 supine normal subjects; the relationship between sleep stages and PRA oscillations was analyzed using 18 nighttime profiles and the concomitant polygraphic recordings of sleep. Blood was collected at 10 min intervals. The slow trends obtained by adjusting a third degree polynomial to the 24 h data were not reproducible among individuals, and no circadian pattern was detected. Sustained oscillations in PRA occurred throughout the day. Spectral analysis revealed that PRA oscillated at a regular periodicity of about 100 min during the night. This periodicity was modified during the day-time by meal intake, which induced PRA peaks with large interindividual variations in size. A close relationship was found between the nocturnal PRA oscillations and the alternance of rapid eye movement (REM) sleep and non-REM sleep. Non-REM sleep invariably coincided with increasing or peaking PRA levels. REM sleep occurred as PRA was declining or at nadirs. More precisely, increases in PRA marked the transition from REM sleep to stage II, stage III and IV usually occurred when PRA was highest. This relationship between the periodic nocturnal oscillations in PRA and the alternance of the REM-non-REM cycles may translate a similar oscillatory process in the CNS or may be linked to hemodynamic changes during sleep that might be partly controlled by the renin-angiotensin system.