Combinatorial roles of the nuclear receptor corepressor in transcription and development
Combinatorial roles of the nuclear receptor corepressor in transcription and development
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DOI：
10.1016/s0092-8674(00)00064-7
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发表时间：
2000-09-15
期刊：
影响因子：
64.5
通讯作者：
Rosenfeld, MG
中科院分区：
文献类型：
--
作者：
Jepsen, K;Hermanson, O;Rosenfeld, MG
转录抑制在后生动物发育的各个方面起着至关重要的作用，这意味着辅抑制因子如N-CoR和SMRT的重要调控作用。来自N-CoR基因缺失小鼠的组织和细胞中转录模式的改变以及由此导致的CNS、红细胞和胸腺细胞发育中特定点的阻滞表明，N-CoR是核受体和MAD的短期主动抑制以及REST/NRSF介导的长期抑制事件的子集的必需组分。出乎意料的是，N-CoR和特定的脱乙酰酶也需要一类视黄酸反应元件的转录激活。总之，这些研究结果表明，特定的辅阻遏物和组蛋白脱乙酰酶的组合介导的基因特异性作用的DNA结合的阻遏物在多器官系统的发展。
Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice and the resulting block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of short-term active repression by nuclear receptors and MAD and of a subset of long-term repression events mediated by REST/NRSF. Unexpectedly, N-CoR and a specific deacetylase were also required for transcriptional activation of one class of retinoic acid response element. Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems.