Bmp7 regulates germ cell proliferation in mouse fetal gonads
Bmp7 regulates germ cell proliferation in mouse fetal gonads
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DOI：
10.1159/000100034
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发表时间：
2007-01-01
影响因子：
2.3
通讯作者：
Capel, B.
中科院分区：
文献类型：
--
作者：
Ross, A.;Munger, S.;Capel, B.
在哺乳动物胎儿性腺分化过程中，调节生殖细胞增殖和性别特异性发育的信号相对较少。骨形态发生蛋白(BMP)家族成员被认为是果蝇性腺生殖细胞的关键调节因子。在这里，我们发现Bmp7在小鼠的性腺中表达，并且是生殖细胞增殖所必需的，在交配后10.5-11.5天之间的一个狭窄的发育窗口中。男性胚胎的增殖缺陷比女性胚胎更严重，这表明存在性别二态补偿途径。在脊椎动物和无脊椎动物中，BMP信号似乎是一条进化保守的途径，调节胚胎生殖细胞的增殖。版权所有(C)2007 S.Karger AG，巴塞尔。
Relatively little is known regarding the signals that regulate the proliferation and sex-specific development of germ cells during mammalian fetal gonad differentiation. Members of the bone morphogenetic protein (BMP) family have been identified as key regulators of germ cells in the Drosophila gonad. Here we show that in mice Bmp7 is expressed in gonads of both sexes and is required for germ cell proliferation during a narrow window of development between 10.5-11.5 days post coitum (dpc). The proliferation defect is more severe in male than in female embryos suggesting that there are sexually dimorphic compensatory pathways. BMP signaling appears to be an evolutionarily conserved pathway regulating embryonic germ cell proliferation in vertebrate and invertebrate species. Copyright (c) 2007 S. Karger AG, Basel.