Depressivity and mortality risk in a cohort of elderly men. A role of cognitive and vascular ill-health, and social participation
Depressivity and mortality risk in a cohort of elderly men. A role of cognitive and vascular ill-health, and social participation
复制标题
DOI：
10.1080/13607863.2019.1597012
复制
发表时间：
2019-04-03
影响因子：
3.4
通讯作者：
Siennicki-Lantz, Arkadiusz
中科院分区：
文献类型：
--
作者：
Jonsson, Max;Siennicki-Lantz, Arkadiusz
目的：老年人的抑郁症状已被证明与死亡率增加有关。本研究的目的是检查老年男性的抑郁症状及其与全因死亡率的关系，以及身体、认知和社会因素是否影响这种关系。研究方法：在703名最初纳入的55岁男性中，我们研究了163名幸存者，他们可以在81岁时参加调查，并跟踪他们直到他们去世。结果如下：Zung抑郁自评量表定义的轻度抑郁症状的男性死亡风险增加（HR = 1.52; CI =1.10-2.08; p = 0.01）。在调整了以下因素后，这种相关性仍然显著：教育，81岁时的整体认知，68岁时的认知能力，血管危险因素和合并症。相反，在调整日常生活活动（ADL）依赖性和参与日常生活的满意度等级后，它被减弱。结论：在存活率高于平均水平的中老年男性中，轻度抑郁症状可预测全因死亡率。认知能力和血管合并症都不能解释这种关联，但参与日常生活的满意度较低，特别是与中度ADL依赖性相结合。
Objectives: Depressive symptoms in the elderly have been shown to be associated with increased mortality. The purpose of this study was to examine symptoms of depression in octogenarian men and their association with all-cause mortality, and whether physical, cognitive and social factors influence this association. Methods: Out of the 703 initially included 55-years-old men, from the prospective cohort study "Men born in 1914", we studied 163 survivors who could take a part in a survey at age 81, and followed them until their death. Results: Those men who had at least mild depressive symptoms, defined with Zung Self-rating Depression Scale, were found to have an increased mortality risk (HR = 1.52; CI =1.10-2.08; p = 0.01). This association persisted significantly after adjusting for: education, global cognition at age 81, cognitive abilities at age 68, vascular risk factors and comorbidities. Instead, it was attenuated after adjustments for Activities of Daily Life (ADL) - dependency and for a grade of Satisfaction with Participation in daily life. Conclusion: In octogenarian men with survival above the average, mild depressive symptoms predict all-cause mortality. Neither cognitive capacity nor vascular comorbidity explained this association, but lower Satisfaction with Participation in daily life, especially in combination with moderate ADL-dependency.