Reflectance spectroscopy for in vivo characterization of ovarian tissue
Reflectance spectroscopy for in vivo characterization of ovarian tissue
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DOI：
10.1002/1096-9101(2001)28:1
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发表时间：
2001-01-01
影响因子：
2.4
通讯作者：
Richards-Kortum, R
中科院分区：
文献类型：
--
作者：
Utzinger, U;Brewer, M;Richards-Kortum, R
背景与目的：探讨反射光谱对卵巢正常、良性肿瘤和卵巢癌的鉴别价值。研究设计/材料与方法：对16例卵巢切除术患者体内64个部位的3种源-检测器分离（SDS）反射光谱（390-600 nm）进行测量。找出统计差异最大的参数。在这些参数的基础上开发了算法并进行了评估。结果：反射强度540 ~ 580 nm （SDS, 1.1 mm）、反射光谱斜率490 ~ 520 nm （SDS, 1.1 mm）、斜率510 ~ 530 nm （SDS, 2.1 mm）、斜率510 ~ 530 （SDS, 3 mm）是有前景的参数。区分卵巢良性肿瘤和恶性肿瘤的平均敏感性和特异性分别为86 +/- 6%和79 +/- 5%。卵巢癌与良性肿瘤和正常卵巢的平均敏感性和特异性分别为86 +/- 4%和80 +/- 8%。结论：反射率光谱在卵巢癌筛查中的应用有待进一步研究。激光外科杂志，2002,28 (C)
Background and Objective: To explore whether reflectance spectroscopy can differentiate normal ovary, benign neoplasms, and ovarian cancer.Study Design/Materials and Methods: Reflectance spectra (390-600 nm) were measured at three source-detector separations (SDS) in vivo at 64 sites in 16 patients undergoing oophorectomy. Parameters with largest statistical differences were identified. Based an these parameters algorithms were developed and evaluated.Results: Promising parameters were the reflectance intensity from 540 to 580 nm (SDS, 1.1 mm), the slope of the reflectance spectrum from 490 to 520 nm (SDS, 1.1 mm), the slope from 510 to 530 nm (SDS, 2.1 mm), and the slope from 510 to 530 (SDS, 3 mm). Average sensitivity and specificity were 86 +/- 6% and 79 +/- 5% to separate normal ovary from benign neoplasms and cancers. Average sensitivity and specificity were 86 +/- 4% and 80 +/- 8% to separate ovarian cancers from benign neoplasms and normal ovary.Conclusion: Reflectance spectroscopy should be further investigated for ovarian cancer screening. Lasers Surg. Med. 28:56-66, 2001 (C) 2001 Wiley-Liss, Inc.