Neural substrates of the cognitive processes underlying spelling: Evidence from MR diffusion and perfusion imaging
Neural substrates of the cognitive processes underlying spelling: Evidence from MR diffusion and perfusion imaging
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DOI：
10.1080/02687030244000248
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发表时间：
2002-04-01
期刊：
影响因子：
2
通讯作者：
Wityk, RJ
中科院分区：
文献类型：
--
作者：
Hillis, AE;Kane, A;Wityk, RJ
背景：尽管关于拼写背后的认知过程有丰富的文献，但对这些过程的神经基础知之甚少。目的：该研究旨在确定与拼写相关的每个认知过程损伤相关的脑功能障碍区域。假设拼写任务的不同组成部分的损伤与急性中风患者的低血流量或梗死的不同区域有关。方法和程序：在左半球中风发病24小时内连续研究80例患者，确定拼写过程各部分损伤与11个布罗德曼区（BAs）中的任何一个灌注不足和/或梗死之间的关联。通过书面命名、单词理解、拼写单词和假词到听写、直接和延迟复制以及大小写转码等测试来识别拼写各部分的损伤。通过MR弥散加权成像和灌注加权成像确定每个BA的梗死和/或灌注不足。用相关矩阵确定显著相关性，用卡方分析证实最强相关性。结果和结果：各种认知过程的损伤与组织功能障碍的不同区域有关。结论：研究得出的结论是，拼写涉及一个相对独立的过程网络，这些过程依赖于不同的大脑区域。
Background: Despite a rich literature on the cognitive processes underlying spelling, there is little known about the neural substrates of these processes.Aims: The study aimed to identify regions of brain dysfunction associated with impairment of each cognitive process underlying spelling. It was hypothesised that impairments of distinct components of the spelling task would be associated with different areas of low blood flow or infarction in acute stroke patients.Methods & Procedures: Associations between impairment of each component of the spelling process and hypoperfusion and/or infarct of any of 11 Brodmann's areas (BAs) were identified in a consecutive series of 80 patients studied within 24 hours of onset of left hemisphere stroke. Impairment of each component of spelling was identified with tests of written naming, word comprehension, spelling words and pseudowords to dictation, direct and delayed copying, and case transcoding. Infarct and/or hypoperfusion in each BA was identified with MR diffusion-weighted imaging and perfusion-weighted imaging. Significant associations were identified with a correlation matrix, and the strongest associations were confirmed with chi square analysis.Outcomes & Results: Impairments of various cognitive processes were associated with separate regions of tissue dysfunction.Conclusions: It was concluded that spelling involves a network of relatively independent processes that rely on different brain regions.