Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort.
Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort.
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DOI：
10.1002/dad2.12380
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发表时间：
2022
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我们的目的是确定睡眠质量和阿尔茨海默病（AD）生物标志物之间的独立关联，以及这些关联是否随年龄而不同。我们纳入了来自欧洲预防阿尔茨海默病v1500.0数据集的1240名年龄≥50岁、无痴呆的个体。使用线性回归来检查匹兹堡睡眠质量指数（PSQI）评分与整个样本和年龄三分位数的脑脊液（CSF）磷酸化tau/β-淀粉样蛋白比率（p-tau/Aβ42）。控制人口统计学、临床、遗传、血管和神经影像学变量的模型。对于年龄最小的三分位数，睡眠时间较短和睡眠效率较高与p-tau/Aβ42比值较高相关。对于年龄最大的三分位数，较长的睡眠潜伏期与较大的p-tau/Aβ42相关。睡眠和AD病理之间的差异关系取决于年龄。睡眠时间短和睡眠效率与中年人有关，而入睡时间与晚年的AD生物标志物关系更密切。这项研究显示了睡眠和AD生物标志物之间联系的年龄差异。睡眠时间短与中年人的p‐tau/Aβ42比值相关。这种关联独立于AD的遗传、血管和神经影像学标志物。
We aimed to determine the independent association between sleep quality and Alzheimer's disease (AD) biomarkers, and whether the associations differ with age. We included 1240 individuals aged ≥50, without dementia from the European Prevention of Alzheimer's Disease v1500.0 dataset. Linear regression was used to examine Pittsburgh Sleep Quality Index (PSQI) scores against cerebrospinal fluid (CSF) phosphorylated tau/β‐amyloid ratio (p‐tau/Aβ42) for the entire sample and via age tertiles. Models controlled for demographic, clinical, genetic, vascular, and neuroimaging variables. For the youngest age tertile, shorter sleep duration and higher sleep efficiency were associated with greater p‐tau/Aβ42 ratio. For the oldest tertile, longer sleep latency was associated with greater p‐tau/Aβ42. Differential relationships between sleep and AD pathology depend on age. Short sleep duration and sleep efficiency are relevant in middle age whereas time taken to fall asleep is more closely linked to AD biomarkers in later life. This study shows age differences in the link between sleep and AD biomarkers. Shorter sleep was associated with greater p‐tau/Aβ42 ratio in middle age. The association was independent of genetic, vascular, and neuroimaging markers of AD.