Prevalence and incidence of sexually transmitted infections among South African women initiating injectable and long-acting contraceptives.
Prevalence and incidence of sexually transmitted infections among South African women initiating injectable and long-acting contraceptives.
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DOI：
10.1371/journal.pone.0294285
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
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南非是性传播感染 (STI) 患病率最高的国家之一，其中包括沙眼衣原体 (CT) 和淋病奈瑟菌 (NG)。 2017 年，南非育龄男性和女性中估计有 600 万新 CT、450 万 NG 和 71 000 例梅毒螺旋体感染。我们评估了居住在南非 eThekwini 和 Tshwane 的 162 名 18-33 岁女性的性传播感染患病率和发病率以及相关危险因素，这些女性是避孕选择和艾滋病毒结果证据 (ECHO) 试验的一部分。女性被随机分配使用长效醋酸甲羟孕酮 (n = 53)、铜宫内节育器 (n = 51) 或左炔诺孕酮 (n = 58) 植入物。在开始避孕之前以及开始避孕后第一个月和第三个月收集阴道侧壁拭子样本以进行性传播感染检测。不同避孕组间性传播感染的发病率和患病率没有显着差异。基线时，40% 的人患有活动性性传播感染（CT、NG、阴道毛滴虫 (TV)、生殖支原体 (MG) 或单纯疱疹病毒 2），所有年龄组均为 18-21 岁 (46%)、22-25 岁 (42%) 和 26-33 岁 (29%)。随访期间性传播感染的发生率异常高 (107.9/100)女性年 [wy]），与 26-33 岁组（17.4/100 wy；p = 0.049）相比，年轻女性（18-21 岁）更有可能获得 CT（75.9/100 wy），与 18-21 岁组（8.4/100 wy）相比，26-33 岁组的 TV 发生率更高（82.7/100 wy）。尽管研究参与者接受了关于使用安全套重要性的广泛咨询，但这项研究强调了南非女性尤其是年轻女性中性传播感染的高患病率和发病率，并强调需要更好的性传播感染筛查和管理策略。
South Africa is among the countries with the highest prevalence of sexually transmitted infections (STIs), including Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). In 2017, there were an estimated 6 million new CT, 4.5 million NG and 71 000 Treponema pallidum infections among South African men and women of reproductive age. We evaluated STI prevalence and incidence and associated risk factors in 162 women aged 18–33 years old, residing in eThekwini and Tshwane, South Africa who were part of the Evidence for Contraceptive Options and HIV Outcomes (ECHO) trial. Women were randomised to use depot medroxyprogesterone acetate (n = 53), copper intrauterine device (n = 51), or levonorgestrel (n = 58) implant. Lateral vaginal wall swab samples were collected prior to contraceptive initiation and at months one and three following contraceptive initiation for STI testing. There were no significant differences in STI incidence and prevalence across contraceptive groups. At baseline, 40% had active STIs (CT, NG, Trichomonas vaginalis (TV), Mycoplasma genitalium (MG) or herpes simplex virus-2 shedding across all age groups– 18–21 years (46%), 22–25 years (42%) and 26–33 years (29%). The incidence of STIs during follow-up was exceptionally high (107.9/100 women-years [wy]), with younger women (18–21 years) more likely to acquire CT (75.9/100 wy) compared to 26–33 year olds (17.4/100 wy; p = 0.049). TV incidence was higher in the 26–33 year old group (82.7/100 wy) compared to the 18–21 year olds (8.4/100 wy; p = 0.01). Although the study participants received extensive counselling on the importance of condom use, this study highlights the high prevalence and incidence of STIs in South African women, especially amongst young women, emphasising the need for better STI screening and management strategies.
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影响因子：
3.1
作者：
Balkus JE;Richardson BA;Rabe LK;Taha TE;Mgodi N;Kasaro MP;Ramjee G;Hoffman IF;Abdool Karim SS
通讯作者：
Abdool Karim SS
影响因子：
3.1
作者：
Kairu A;Masson L;Passmore JS;Cunnama L;Sinanovic E
通讯作者：
Sinanovic E
影响因子：
3.6
作者：
Deese J;Philip N;Lind M;Ahmed K;Batting J;Beksinska M;Edward VA;Louw CE;Onono M;Palanee-Phillips T;Smit JA;Baeten JM;Donnell D;Mastro TD;Mugo NR;Nanda K;Rees H;Morrison C
通讯作者：
Morrison C
影响因子：
168.9
作者：
Baeten, Jared M.;Donnell, Deborah;Stringer, Jeffrey
通讯作者：
Stringer, Jeffrey
影响因子：
4.4
作者：
Deese, Jennifer;Chen, Pai Lien;Gao, Xiaoming;Heffron, Renee;Hobbs, Marcia;Lapple, Dana;Jaspan, Heather;Miller, Ashley;Nair, Gonasagrie;Onono, Maricianah;Palanee-Phillips, Thesla;Reddy, Krishnaveni;Steiner, Markus J.
通讯作者：
Steiner, Markus J.