Difluorocarbene-based cyanodifluoromethylation of alkenes induced by a dual-functional Cu-catalyst.
Difluorocarbene-based cyanodifluoromethylation of alkenes induced by a dual-functional Cu-catalyst.
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DOI：
10.1039/d1cc00160d
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发表时间：
2021-02
影响因子：
4.9
通讯作者：
Min Zhang;Jin‐Hong Lin;Chuan‐Ming Jin;Ji-Chang Xiao
中科院分区：
文献类型：
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作者：
Min Zhang;Jin‐Hong Lin;Chuan‐Ming Jin;Ji-Chang Xiao
虽然氰氟烷基化已受到越来越多的关注，但通常需要有毒的氰化试剂。本文介绍了在光催化条件下，以BrCF 2CO 2 Et/NH 4 HCO 3为催化剂，Cu为催化剂催化烯烃的氰基二氟甲基化反应。BrCF 2CO 2 Et和NH 4 HCO 3分别用作腈基的碳源和氮源，避免了使用化学计量的有毒氰化试剂。铜络合物起着双重作用。它不仅是一种光催化剂，也是一种形成C-CN键的偶联催化剂。
Although cyanofluoroalkylation has received increasing attention, a toxic cyanation reagent is usually required. Herein, a Cu-catalyzed difluorocarbene-based cyanodifluoromethylation of alkenes with BrCF2CO2Et/NH4HCO3 under photocatalytic conditions is described. BrCF2CO2Et and NH4HCO3 serve as a carbon source and a nitrogen source of the nitrile group, respectively, avoiding the use of a stoichiometric toxic cyanation reagent. The Cu-complex plays a dual role. It is not only a photocatalyst, but also a coupling catalyst for the formation of a C-CN bond.