Metapopulation concepts applied to falciparum malaria and their impacts on the emergence and spread of chloroquine resistance
Metapopulation concepts applied to falciparum malaria and their impacts on the emergence and spread of chloroquine resistance
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DOI：
10.1016/s1567-1348(02)00099-0
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发表时间：
2003-02-01
影响因子：
3.2
通讯作者：
Robert, Vincent
中科院分区：
文献类型：
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作者：
Ariey, Frederic;Duchemin, Jean-Bernard;Robert, Vincent
集合种群的结构研究是传染病群体遗传学的一个新概念，特别适用于寄生虫种群的分析。我们认为这一理论的一个应用集中在恶性疟原虫种群。我们的研究包括三个主要步骤：方法的相关性，使用集合种群概念的简化模型的建议，以及对抗疟药物耐药性后果的探索。我们的主要结果涉及的集合种群结构，是适当的，在某些真实的情况。在热带非洲农村，寄生虫种群可以被认为是斑块状的，与panmictic情况相当，其中与高患病率（通常高于50%）相关的高传播率意味着亚种群之间没有发生差异。与此相反，在亚洲和南美洲，有很大的变化在地方性（与流行率范围从0到100%）符合一个典型的集合种群动态结构和斑块之间的分化概率高。这些研究结果与观察到的氯喹耐药性在东南亚和南美出现而非非洲的情况相一致，并与其在引入后迅速蔓延的情况相一致。(C)2002 Elsevier Science B.V.保留所有权利。
Studying the structure of metapopulations is a new concept in population genetics of infectious diseases that is particularly adapted to the analysis of parasite populations. We considered one application of this theory focusing on Plasmodium falciparum populations. Our study consisted of three main steps: the relevance of the approach, the proposal of a simplified model using metapopulation concepts, and the exploration of the consequences on antimalarial drug resistance. Our main result concerns the metapopulation structure that is appropriate in some real situations. In intertropical rural Africa, parasite populations can be considered to be patchy, comparable to the panmictic situation in which a high transmission rate associated with a high prevalence (generally higher than 50%) implies that no diferenciation occurs between sub populations. In contrast, in Asia and South America, there are great variations in endemicity (with prevalences ranging from 0 to 100%) consistent with a typical metapopulation dynamic structure and a high probability of differentiation between patches. These findings agree with the observed emergence of chloroquine resistance in south-east Asia and South American but not in Africa, and with its rapid spread following its introduction. (C) 2002 Elsevier Science B.V. All rights reserved.