CRISPR-Cas has a new juggling act: interplay between nuclease and protease.
CRISPR-Cas has a new juggling act: interplay between nuclease and protease.
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CRISPR-Cas 有一种新的杂技：核酸酶和蛋白酶之间的相互作用。
DOI：
10.1038/s41594-022-00917-1
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发表时间：
2023
影响因子：
16.8
通讯作者：
Fu,Tian-Min
中科院分区：
文献类型：
--
作者：
Rish,AnthonyD;Fu,Tian-Min
Craspase 是新发现的 III 型 CRISPR-Cas 系统，具有两个主要组件：核酸酶 Cas7-11 和蛋白酶 TPR-CHAT。 Craspase 在核酸酶和蛋白酶活性之间发挥微妙的平衡作用，以实现细菌的免疫耐受和防御，并显示出作为高度可调节的基因组编辑工具的前景。
Craspase is newly identified type III CRISPR–Cas system with two major components: the nuclease Cas7-11, and the protease TPR-CHAT. Craspases perform a delicate balancing act between nuclease and protease activity to achieve immune tolerance and defense in bacteria, and show promise as highly regulatable genome-editing tools.