The intrinsic radiosensitivity of normal and tumour cells
The intrinsic radiosensitivity of normal and tumour cells
复制标题
正常细胞和肿瘤细胞的内在辐射敏感性
DOI：
10.1080/095530098142248
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发表时间：
1998-04-01
影响因子：
2.6
通讯作者：
Hendry, JH
中科院分区：
文献类型：
--
作者：
West, CML;Davidson, SE;Hendry, JH
目的：探讨正常细胞和肿瘤细胞体外放射敏感性测定是否可作为临床肿瘤学预后指标。材料和方法：对I-III期宫颈癌患者进行根治性放射治疗，至少随访3年。淋巴细胞和肿瘤的放射敏感性分别采用极限稀释法和软琼脂克隆形成法检测，以获得2GySF2的存活分数。结果：使用放射敏感淋巴细胞的患者发生晚期并发症的风险显著增加(n=93，p=0.002)。肿瘤放射敏感性的增加与发病率的增加有关(n=113，p=0.032)。成纤维细胞与肿瘤细胞放射敏感性呈显著正相关(r=0.57，p=0.03)，而淋巴细胞与肿瘤细胞放射敏感性呈弱负相关(r=-0.32，p=0.03)。具有放射敏感性的淋巴细胞和肿瘤细胞的患者的晚期并发症水平高于那些细胞具有放射抗性的患者。结论：所描述的工作强调了细胞的放射敏感性作为决定放射治疗临床反应的参数的重要性。
Purpose: To examine whether in vitro measurements of normal and tumour cell radiosensitivity can be used as prognostic factors in clinical oncology.Materials and methods: Stage I-III cervix carcinoma patients were treated with radical radiotherapy with a minimum of 3 years' follow-up. Lymphocyte and tumour radiosensitivities were assayed using, respectively, a limiting dilution and soft agar clonogenic assay to obtain surviving fraction at 2 Gy (SF2). The results were related, in an actuarial analysis, to late morbidity assessed using the France-Italian glossary.Results: Patients with radiosensitive lymphocytes had a significantly increased risk of developing late complications (n=93, p=0.002). Increasing tumour radiosensitivity was associated with an increased risk of morbidity (n=113, p=0.032). ii significant correlation was found between fibroblast and tumour cell radiosensitivity (r=0.57, p=0.03), but a weak inverse association was found between lymphocyte and tumour cell radiosensitivity (r= -0.32, p=0.03). Patients with radiosensitive lymphocytes and tumour cells had higher levels of late complications than those whose cells were radioresistant.Conclusion: The work described highlights the importance of cellular radiosensitivity as a parameter determining the clinical response to radiotherapy.