Rechargeable Antibacterial Polysulfonamide-Based N-Halamine Nanofibrous Membranes for Bioprotective Applications.
Rechargeable Antibacterial Polysulfonamide-Based N-Halamine Nanofibrous Membranes for Bioprotective Applications.
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DOI：
10.1021/acsabm.9b00537
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发表时间：
2019-07
影响因子：
4.7
通讯作者：
Feiyan Wang;Mei Liu;Ruida Ding;Mingguang Liang;Liqian Huang;Jianyong Yu;Y. Si
中科院分区：
文献类型：
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作者：
Feiyan Wang;Mei Liu;Ruida Ding;Mingguang Liang;Liqian Huang;Jianyong Yu;Y. Si
具有杀菌活性的生物防护材料可在很大程度上保护医护人员免受新发传染病的感染；然而，创造这样的材料被证明是极具挑战性的。在这里，我们通过路易斯酸辅助氯化工艺制备了一种具有可充电和快速杀菌性能的新型聚磺胺（PSA） N-halamine静电纺纳米纤维膜。氯化过程中，PSA分子链之间的氢键通过Lewis酸碱络合作用被削弱，使得更多有效的酰胺基团被氯化成N-halamine杀生基团。由此产生的纳米纤维膜具有有趣的特性，如可再充氯化能力（> 4500ppm）、快速杀菌活性（1分钟内细菌减少6对数）、高颗粒去除效率（>99.8%）、长期耐用性和易于扩展生产，这可以被视为一种功能防护设备层，不仅能够拦截病原体，还能有效地灭活病原体。PSA n -卤胺抗菌纳米材料的成功合成，为生物防护材料的多功能化和可充电化发展开辟了新的途径。
Bioprotective materials with bactericidal activity could largely protect healthcare workers from being infected by emerging infectious diseases; however, creating such materials has turned out to be extremely challenging. Here, we fabricate a novel polysulfonamide (PSA) N-halamine electrospun nanofibrous membrane with rechargeable and rapid bactericidal properties by a Lewis acid-assisted chlorination process. The hydrogen bonds between PSA molecular chains can be weakened through Lewis acid-base complexation during chlorination, enabling more available amide groups to be chlorinated into N-halamine biocidal groups. The resulting nanofibrous membranes render intriguing features such as rechargeable chlorination capability (>4500 ppm), rapid bactericidal activity (6 log reduction of bacteria in 1 min), high particle removal efficiency (>99.8%), long-term durability, and ease of scalable production, which can be perceived as a functional layer of protective equipment that is capable of not only intercepting but also inactivating the pathogens effectively. The successful synthesis of the PSA N-halamine antibacterial nanomaterials opens new ways toward the development of bioprotective materials in a multifunctional and rechargeable form.